GIP receptor agonism and the argument about direction — setting out what I have, and where I think it stops being reliable.
A question about GIP receptor agonism that I think has a definite answer, unlike most of what I ask here.
I have the reasoning below and I am fairly confident about the direction. I am not confident about the size, and the size is what the decision turns on.
The opening post answers the question as asked. The question underneath it is different.
GLP-1 receptor signalling: the GLP-1 receptor is expressed on beta cells (insulin secretion), on neurons (appetite and gastric motility), and on myocardium (contractility). Different tissues respond to the same signal in different ways.
Clear enough that I do not think I have a follow-up, which is unusual.
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