Compounds · Retatrutide

Retatrutide's phase 2 heart-rate signal and how to think about it — the long version

Compounds › Retatrutide effect size randomised trial TRIUMPH programme

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Solved by r.ekstrom in post #3

The phase 2 obesity paper reported dose-dependent weight reduction of a magnitude that attracted attention. It also reported dose-dependent heart-rate increases. The heart-rate signal is the reason phase 3 exists rather than something assumed negligible based on phase 2. Scoping that to what I have actually seen…

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n.hartmannTL218 Dec 2024#1

Retatrutide's phase 2 heart-rate signal and how to think about it — the long version Writing it up because I had to work it out twice and would rather nobody else did.

Putting the numbers in the first post, because a question about a compound without them turns into a question about somebody's impression of it.

retatrutide, monoisotopic mass near 4731.3 Da, 17 weeks of my own notes, and 5 lots from 3 suppliers with a purity figure on each. That is the whole basis of what follows.

What I want checked is the reasoning I have built on top of it, not the figures themselves.

11 likes 19mo

chromatogramTL4Analytical chemist2 Feb 2025#2

The opening post is the version of this I will quote in future. One addition.

Nausea and vomiting were dose-related in the phase 2 work, as they are throughout this class. What is not established is whether the tolerability profile differs from the dual agonists at equipotent effect, because equipotence has not been established either.

1 like 18mo

r.ekstromTL2 Solution7 Mar 2025#3

The phase 2 obesity paper reported dose-dependent weight reduction of a magnitude that attracted attention. It also reported dose-dependent heart-rate increases. The heart-rate signal is the reason phase 3 exists rather than something assumed negligible based on phase 2.

Scoping that to what I have actually seen rather than what I have read.

30 likes 17mo

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