This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1 · go to the accepted answer.
Holding a dose indefinitely: the trials did not study indefinite holding at a non-maximum dose. The trials escalated to a target and then held that. What happens if you stay at an intermediate dose for years is not formally studied and extrapolation is the best available reasoning.
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Holding a dose indefinitely: is there a documented downside?
Holding a dose indefinitely: is there a documented downside? — that is the question, and I have not found it answered plainly anywhere I have looked. I have read the maintained page on this and I still have a…
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+28 | 32 | 57k | 12mo |
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Why "dose equivalence" between different incretin analogues is a weak concept
Why "dose equivalence" between different incretin analogues is a weak concept I have a specific reason for asking rather than idle curiosity, and the context is below. I have read the maintained page on this…
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+124 | 133 | 11k | 5mo |
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Where the four-week escalation interval comes from, and what it is not
On the subject in the title: Where the four-week escalation interval comes from, and what it is not Working notes rather than a conclusion. Working notes on four-week escalation interval rather than a…
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+56 | 60 | 21k | 2y |
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Micro-titration: a disputed topic, argued properly
Micro-titration: a disputed topic, argued properly Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers on…
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+99 | 110 | 61k | 2d |
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Follow-up: The lowest dose that does anything: is that a real question?
The question in the title: The lowest dose that does anything: is that a real question? I will give what I have already checked below so nobody repeats it. I have read the maintained page on this and I still…
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+70 | 75 | 12k | 8mo |
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Tirzepatide's shorter half-life and its one practical consequence
On the subject in the title: Tirzepatide's shorter half-life and its one practical consequence Working notes rather than a conclusion. Documentation question rather than a pharmacological one, but about this…
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+18 | 29 | 20k | 8mo |
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When a dose reduction is the correct response to a side effect — a second dataset
When a dose reduction is the correct response to a side effect — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. Posting a small dataset on dose…
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+10 | 14 | 42k | 2mo |
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Why we ask for units every single time, with three examples of what goes wrong — what changed since
The question in the title: Why we ask for units every single time, with three examples of what goes wrong — what changed since I will give what I have already checked below so nobody repeats it. Counting it…
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+14 | 18 | 19k | 2mo |
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The arithmetic of an intermediate dose between two label steps
On the subject in the title: The arithmetic of an intermediate dose between two label steps Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am…
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2 | 136 | 2mo | |
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Follow-up: Why the titration planner refuses to produce a schedule below a floor
The question in the title: Why the titration planner refuses to produce a schedule below a floor I will give what I have already checked below so nobody repeats it. A follow-up question about titration…
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+120 | 146 | 14k | 10mo |