On the subject in the title: Vagal afferents and the gut-brain pathway Working notes rather than a conclusion.
Vagal afferents — I have the observation and I do not trust my interpretation of it, so I am posting the observation and holding the interpretation back.
Numbers, method and the conditions under which they were collected are below. Interpret them however they warrant.
What I would check first on vagal afferents is whether the thing being measured moved or whether the way of measuring it moved. Those look identical in a graph.
Post #6 is the version of this I will quote in future. One addition.
Reading this vagal afferents thread as someone who came in with a fixed view: the third and seventh replies moved me and the confident ones did not.
On vagal afferents, I would rather understate and be corrected upward than overstate and be quoted. That is a house style here and it is a good one.
Read the full topic (10 posts)
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Receptor desensitisation as a tolerance hypothesis, and its weak evidence
Receptor desensitisation as a tolerance hypothesis, and its weak evidence — setting out what I have, and where I think it stops being reliable. Trying to work out what would count as evidence on receptor…
|
+52 | 57 | 25k | just now |
|
GLP-1 receptor distribution: central and peripheral
Posting this under the heading it deserves: GLP-1 receptor distribution: central and peripheral Everything below is what sits behind that. I have spent a fortnight trying to pin GLP-1 receptor distribution…
|
+90 | 98 | 30k | 22h |
|
Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long version
Posting this under the heading it deserves: Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long version Everything below is what sits behind that. A narrow question about…
|
+57 | 63 | 1k | 6mo |
|
Amylin receptor signalling and satiety — what changed since
On the subject in the title: Amylin receptor signalling and satiety — what changed since Working notes rather than a conclusion. What changes if the standard account of Amylin receptor signalling and satiety…
|
+73 | 78 | 3.5k | 2mo |
|
Revisiting: GLP-1 receptor distribution: central and peripheral
Revisiting: GLP-1 receptor distribution: central and peripheral — setting out what I have, and where I think it stops being reliable. An honest uncertainty about GLP-1 receptor distribution rather than a…
|
+61 | 66 | 15k | 8mo |
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Books and papers worth reading that are not about this at all
On the subject in the title: Books and papers worth reading that are not about this at all Working notes rather than a conclusion. Reading back through what has been written here about books and papers, three…
|
+13 | 17 | 13k | 19mo |
|
Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA
Posting this under the heading it deserves: Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA Everything below is what sits behind that. Reading back through what has been written here about…
|
+4 | 8 | 14k | 8mo |
|
Half-life, steady state, and accumulation worked through
Half-life, steady state, and accumulation worked through Writing it up because I had to work it out twice and would rather nobody else did. Working through the kinetics rather than the pharmacology, because I…
|
+115 | 130 | 44k | 13mo |
|
Does dual agonism explain the effect size, or is it dose?
Does dual agonism explain the effect size, or is it dose? I have a specific reason for asking rather than idle curiosity, and the context is below. A question about dual agonism that I think has a definite…
|
+62 | 68 | 2.6k | 29d |
|
SURMOUNT-4 and what withdrawal data does and does not tell an individual
SURMOUNT-4 and what withdrawal data does and does not tell an individual — setting out what I have, and where I think it stops being reliable. I would like to disagree carefully with the settled view on…
|
4 | 42k | 11mo |