Knowlton
TL3 Regular · Szeged, HU
Clinician. Posts general information only, and says so every time.
Joined 27 October 2024 · last posted 2d · groups: clinicians
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Peak-to-trough ratio at steady state for a weekly agent — the long version Replied, post #61 · Pharmacology › Pharmacokinetics · 26 Jul 2026 · 11 likes Coming back to post #57, because the follow-up matters more than the original answer. Steady state is approached in roughly four to five half-lives. For a compound with…
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Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #69 · Practice › Interactions · 25 Jul 2026 · 2 likes Right, and stated more narrowly than I would have dared to state it.
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Journal club: what we got wrong in an earlier session Replied, post #118 · Evidence › Journal club · 25 Jul 2026 · 31 likes The most common failure mode is spending fifty minutes on the effect size and ten on the population. Reversing that ratio would improve most sessions.
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Coming back to: Telehealth prescribing models in the US Replied, post #27 · Regional › North America · 24 Jul 2026 · 10 likes What I would want before treating Telehealth prescribing models as settled: the method, the sample, and whether anyone tried to find the opposite result. Two of the…
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What a certificate commits its issuer to Replied, post #94 · Analytics › COA interpretation · 24 Jul 2026 · 5 likes An itemised related-substances table with retention times says considerably more about the synthesis than a single total. A total tells you how much is not the main…
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Coming back to: Where the four-week escalation interval comes from, and what it is not Replied, post #40 · Practice › Dosing & titration · 22 Jul 2026 · 29 likes The four-week escalation interval is a convention from the pivotal trials, not a pharmacological constant. The pharmacological argument is that with a week-long…
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[2026 update] Regional warehouse stock versus direct despatch Replied, post #138 · Sourcing › Logistics · 18 Jul 2026 · 7 likes Posting my Regional warehouse stock versus direct numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by someone…
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NHS criteria and how they are applied in practice Replied, post #33 · Regional › UK & Ireland · 17 Jul 2026 · 18 likes Small methodological point on NHS criteria: repeating a measurement is cheap and resolves most of what is being argued about here at no cost to anyone.
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Here for the analytics and not much else Replied, post #28 · Lounge › Introductions · 13 Jul 2026 · 6 likes There is: the practice category, and the calculators, both written for exactly that. Nothing there assumes chemistry, and the maintained documents show their working so…
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Insurance and replacement policies, compared Replied, post #78 · Sourcing › Logistics · 10 Jul 2026 · 22 likes Narrowing post #77, because the general version has more than one answer. Insurance and carrier liability: most parcel carriers limit liability. Understanding the…
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Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #87 · Evidence › Journal club · 7 Jul 2026 · 0 likes On post #86 — agreed on the reasoning, with one qualification. Sessions on negative or null results are consistently the most instructive and the hardest to get anyone…
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[2026 update] Area percent versus weight percent: the confusion that causes most arguments Replied, post #68 · Analytics › HPLC & UHPLC · 6 Jul 2026 · 15 likes On post #66 — agreed on the reasoning, with one qualification. Area percent is a proportion of absorbance, not a proportion of mass. Two species with different…