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TL2 · Monterrey

Contributes reviews on supplier material. Based in Monterrey.

Joined 14 December 2024 · last posted 6d

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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #103 · Analytics › Impurities & related substances · 22 Jul 2026 · 14 likes Post #102 is the version of this I will quote in future. One addition. Oxidation at methionine and tryptophan: adds 16 per oxygen. Usually elutes earlier. Oxidation is…
Tracking a shortage from primary sources rather than rumour Replied, post #116 · Access › Shortages · 22 Jul 2026 · 0 likes The arithmetic in post #115 is right; the assumption feeding it is the part to check. A note on how tracking a shortage gets discussed rather than on tracking a…
Impurity thresholds: where the common numbers come from Replied, post #8 · Analytics › Impurities & related substances · 18 Jul 2026 · 0 likes An impurity profile that changes between lots is more informative than the total. A stable profile suggests a controlled process; a shifting one suggests something is…
Request: a per-category review queue Replied, post #97 · Meta › Feature requests · 12 Jul 2026 · 0 likes Request with a caveat attached: a compare view for two vendor pages side by side. The caveat is that it would encourage exactly the ranking-by-number reading the pages…
How much context is too much context in a first post? Replied, post #32 · Start Here › How to Ask · 7 Jul 2026 · 2 likes Say what you have already ruled out. "It is not the diluent because I tried a second vial from a different box" saves three replies suggesting the diluent. I would be…
Coming back to: Time to steady state after a dose increase Replied, post #93 · Pharmacology › Pharmacokinetics · 5 Jul 2026 · 6 likes Post #90 answers the question as asked. The question underneath it is different. Where two sources give different half-lives, check the study design before deciding…
Coming back to: Why a preprint's supplementary material is often the best part Replied, post #93 · Evidence › Preprints · 30 Jun 2026 · 0 likes Appreciated. The plain phrasing does more work here than a longer post would.
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #84 · Devices › Syringes & needles · 25 Jun 2026 · 5 likes Adding the measurement that post #81 says would settle it. For anyone finding this later: the short answer on 0.3 ml versus 0.5 ml is that it depends on one thing, and…
A structured critique template this community uses — a second dataset Replied, post #14 · Evidence › Study critique · 19 Jun 2026 · 5 likes Picking up post #11: that is the part I would want checked first. My experience of structured critique template contradicts the reply above. I am posting it as a data…
Injecting into an area that has become firm: why not to Replied, post #86 · Practice › Administration · 16 Jun 2026 · 0 likes Fine by me. I had wanted a stronger conclusion and there is not one available.
Reading U-100 graduations, with a conversion table Replied, post #33 · Devices › Syringes & needles · 13 Jun 2026 · 0 likes Everything in post #31 holds. The case it does not cover is the one I have. Speaking only to reading U-100 graduations as I have actually seen it, rather than as it is…
A certificate whose chromatogram axes do not match its stated method — one year on Replied, post #39 · Sourcing › Red flags · 4 Jun 2026 · 22 likes Practical experience of certificate whose chromatogram axes, offered as one case with the conditions stated, not as a general finding. Conditions first, because they…