Being outside the studied population does not mean a treatment is unsafe. It means the usual evidence is not available and the reasoning has to be explicit.
That has been true for the cases I have seen and I have not seen many.
I read post #15 twice before replying, because I had assumed the opposite.
I have no financial interest in anything named in this thread and I want to say so before I comment on Athletes in weight-category sports, because it is the sort of subject where it matters.
I have three months of notes on Athletes in weight-category sports and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly drew the opposite conclusion from the first fortnight.
Read the full topic (42 posts)
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Hepatic impairment and the absence of data — a second dataset
On the subject in the title: Hepatic impairment and the absence of data — a second dataset Working notes rather than a conclusion. Posting a small dataset on Hepatic impairment. It is mine, it is…
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2 | 4.3k | 4mo | |
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Older adults, sarcopenia risk, and the trade-off nobody quantifies — does this still hold?
Asking directly, because I could not find a straight answer: Older adults, sarcopenia risk, and the trade-off nobody quantifies — does this still hold? Older adults: setting out the arithmetic in full,…
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2 | 22k | 11mo | |
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Pregnancy and pregnancy planning: contraindication and washout
Posting this under the heading it deserves: Pregnancy and pregnancy planning: contraindication and washout Everything below is what sits behind that. Pregnancy and pregnancy planning: setting out the…
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+111 | 122 | 2.4k | 3mo |
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Adolescents: a distinct evidence base
Adolescents: a distinct evidence base Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of adolescents is wrong? I ask because I have been…
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3 | 11k | 9h | |
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Adolescents: a distinct evidence base — one year on
Posting this under the heading it deserves: Adolescents: a distinct evidence base — one year on Everything below is what sits behind that. A methods question rather than a substantive one, about Adolescents.…
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+78 | 88 | 9.3k | 3mo |
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A history of disordered eating: proceeding carefully
A history of disordered eating: proceeding carefully Writing it up because I had to work it out twice and would rather nobody else did. I would like to disagree carefully with the settled view on history of…
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+70 | 75 | 10k | 6mo |
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Renal impairment: what the labelling says about dose
On the subject in the title: Renal impairment: what the labelling says about dose Working notes rather than a conclusion. A methods question rather than a substantive one, about renal impairment. Everyone…
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4 | 8.9k | 19mo | |
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Adolescents: a distinct evidence base — one year on
Posting this under the heading it deserves: Adolescents: a distinct evidence base — one year on Everything below is what sits behind that. A methods question rather than a substantive one, about Adolescents.…
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+78 | 88 | 9.3k | 3mo |
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Follow-up: Conditions that change the calculus rather than forbidding it
Posting this under the heading it deserves: Conditions that change the calculus rather than forbidding it Everything below is what sits behind that. I was wrong about Conditions in a thread last spring and I…
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+30 | 34 | 62k | 2y |
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Severe gastroparesis and why this class is a poor fit
On the subject in the title: Severe gastroparesis and why this class is a poor fit Working notes rather than a conclusion. I was wrong about severe gastroparesis in a thread last spring and I would like to…
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3 | 62k | 13mo |