Posting this under the heading it deserves: Washout: how long is long enough, and for what purpose Everything below is what sits behind that.
A narrow question about Washout, deliberately narrow, because the broad version has been asked here four times and produced four long threads and no answer.
One question, stated units, stated method, and what I have already ruled out.
I changed my mind about Washout after someone here asked me for the source and I could not produce one. That is worth saying out loud because it is the ordinary way it happens.
Everything in post #42 holds. The case it does not cover is the one I have.
Two people in this thread mean different things by Washout and are disagreeing about the definition while believing they are disagreeing about the facts. Worth pausing to define it.
I disagree with the framing of Washout above, and I think it is a substantive disagreement rather than a terminological one. Setting out why, so it can be checked.
The reasoning depends on an assumption that is doing a lot of work and is never stated. If the assumption holds, the conclusion follows. I do not think it holds generally.
Grateful for the specificity. Vague answers to this question are what sent me looking.
A pharmacokinetic model fitted to trial data describes the population studied. Applying it to somebody outside the enrolled range is an extrapolation, and the model will not tell you it is.
Not a conclusion. A place to stand while looking for one.
Post #136 and I disagree about the size of the effect, not about the direction.
Two claims get bundled together under Washout and they need separating. The descriptive one — this is what was observed — is usually well supported. The causal one — this is why — usually is not.
Almost every disagreement in threads like this one dissolves once you say which of the two you are making.
Read the full topic (140 posts)
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About the Pharmacokinetics category
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