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Outcomes · Body composition

DXA precision and the least significant change for lean mass

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ZC
z.cardosoTL214 Nov 2025#1

Posting this under the heading it deserves: DXA precision and the least significant change for lean mass Everything below is what sits behind that.

A question about measurement precision rather than about physiology.

Two readings, some weeks apart, on the same equipment, differing by an amount that feels meaningful and may not be. I do not know what this instrument's least significant change actually is.

How much difference does there have to be before it is a difference?

0 likes 8mo
VS
v.sjobergTL215 Nov 2025#2

On the opening post — agreed on the reasoning, with one qualification.

DXA on the same machine with the same technician has a least significant change for lean mass of roughly a kilogram, sometimes more. Below that, two scans are the same scan.

0 likes 8mo
TV
t.vasquezTL4 Moderator16 Nov 2025#3

The most useful protocol is the one you will actually repeat identically. An imperfect measurement repeated consistently beats a better one repeated carelessly.

8 likes 8mo
NL
n.laurentTL216 Nov 2025#4
t.vasquez, post #3: The most useful protocol is the one you will actually repeat identically. An imperfect measurement repeated consistently beats a better one repeated carelessly. Go to post

Resting metabolic rate: body composition affects metabolic rate. As fat mass decreases and lean mass is maintained, metabolic rate is usually maintained better than with simple weight loss alone.

I would put the burden of proof on the interesting explanation, not the dull one.

19 likes in reply to #3 8mo
MA
m.achebeTL217 Nov 2025#5
z.cardoso, post #1: Posting this under the heading it deserves: DXA precision and the least significant change for lean mass Everything below is what sits behind that. A question about measurement precision rather than about physiology. Two readings, some weeks apart, on the same equipment, differing by an amount that feels meaningful and may not be. I do… Go to post

Adding the measurement that post #4 says would settle it.

Where a scan disagrees with the mirror over a short period, the scan's precision limits are usually the explanation.

0 likes in reply to #1 8mo
NP
n.petrovTL218 Nov 2025#6

Grateful for the specificity. Vague answers to this question are what sent me looking.

2 likes 8mo
BN
b.nilsenTL218 Nov 2025#7

Counterpoint on DXA precision, offered without confidence: the same observation is consistent with a much duller explanation, and nobody has ruled the dull one out.

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MR
m.rasmussenTL219 Nov 2025 · edited#8

On DXA precision I would separate what is worth knowing from what is worth acting on. The first list is long and the second is short, and conflating them is how threads get heated.

26 likes 8mo
BV
bias_varianceTL4Biostatistician20 Nov 2025#9
t.vasquez, post #3: The most useful protocol is the one you will actually repeat identically. An imperfect measurement repeated consistently beats a better one repeated carelessly. Go to post

Neither method is capable of detecting the month-to-month changes that people report detecting month to month.

20 likes in reply to #3 8mo
MS
m.steinerTL220 Nov 2025#10
m.achebe, post #5: Adding the measurement that post #4 says would settle it. Where a scan disagrees with the mirror over a short period, the scan's precision limits are usually the explanation. Go to post

Bioelectric impedance analysis: less precise than DXA and strongly affected by hydration state. Not reliable for detecting month-to-month changes. Useful for trend over years if done consistently.

The answer changed when I changed how I was measuring, which was informative.

0 likes in reply to #5 8mo
OF
outline_firstTL321 Nov 2025#11
SO
se.okaforTL221 Nov 2025#12
n.petrov, post #6: Grateful for the specificity. Vague answers to this question are what sent me looking. Go to post

Precision versus accuracy: the precision you need depends on what question you are answering. "Am I losing fat?" requires less precision than "Is my lean mass preservation within the expected range?"

For what it is worth, the same held on the two occasions I checked.

6 likes in reply to #6 8mo
SB
sharps_binTL2Regular22 Nov 2025#13

Useful. I have added it to my own notes with the date on it.

1 like 8mo
IB
i.boatengTL222 Nov 2025 · edited#14

Adding the measurement that post #12 says would settle it.

Lean mass loss during rapid weight reduction: depends on protein intake, resistance training volume, and total energy deficit. Adequate protein and maintaining training intensity both help preserve lean mass.

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SS
steady_stateTL3Regular23 Nov 2025#15

Maintenance phase: tracking body composition during maintenance (weight stable) is different from tracking during active loss. Changes are smaller and precision becomes more important.

That is the practical version. The rigorous version is longer and says the same thing.

22 likes 8mo
NC
n.cabreraTL223 Nov 2025#16
bias_variance, post #9: Neither method is capable of detecting the month-to-month changes that people report detecting month to month. Go to post

Comparison to published data: the trials reported mean fat and lean mass changes. Individual results vary around that mean. Being above or below average is not a sign of something wrong.

10 likes in reply to #9 8mo
EF
e.ferreiraTL3Regular24 Nov 2025#17

Answering the question post #14 raises rather than the one it answers.

I have no financial interest in anything named in this thread and I want to say so before I comment on DXA precision, because it is the sort of subject where it matters.

3 likes 8mo
BK
b.kowalskiTL224 Nov 2025#18

The version of DXA precision that circulates here is a simplification of a simplification. It is not wrong, but it has lost the conditions under which it holds, and those conditions are where the interesting cases live.

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DH
dietitian_hollisTL3Dietitian25 Nov 2025#19

Lean mass in these measurements includes water, so a change in hydration appears as a change in lean mass.

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RE
r.erdoganTL225 Nov 2025#20

Post #17 is right about the mechanism and I think understates the practical bit.

What I can speak to on DXA precision is narrow, so I will keep it narrow rather than generalising from it. Beyond that boundary I do not know.

1 like 8mo
JN
j.nwosuTL225 Nov 2025#21

I came in to disagree and I am leaving without a disagreement.

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NS
n.stanescuTL226 Nov 2025#22

Post #20 and I disagree about the size of the effect, not about the direction.

Visceral fat: DXA does not distinguish visceral (organ-associated) fat from subcutaneous fat. That distinction might matter but requires different imaging to measure.

The rule of thumb is fine; the edge cases are where it earns its keep.

0 likes 8mo
SC
s.cardosoTL226 Nov 2025#23
BP
b.petrovTL227 Nov 2025#24
r.erdogan, post #20: Post #17 is right about the mechanism and I think understates the practical bit. What I can speak to on DXA precision is narrow, so I will keep it narrow rather than generalising from it. Beyond that boundary I do not know. Go to post

Distinguishing three things in the DXA precision discussion that keep getting used interchangeably: the observation, the proposed mechanism, and the recommendation that gets attached to both.

16 likes in reply to #20 8mo
JM
j.mwangiTL4 Moderator27 Nov 2025#25

This follows post #22 rather than contradicting it.

Where I would push back on the DXA precision consensus is the confidence, not the direction. The direction looks right. The confidence is borrowed.

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DE
d.eriksenTL228 Nov 2025#26

Air displacement plethysmography and hydrostatic weighing have their own precision limits and their own protocol sensitivities. None of these are exact.

This is the version I would want a new member to read first.

1 like 8mo
NH
n.haddadTL228 Nov 2025 · edited#27

DXA (dual-energy X-ray absorptiometry): the standard for body composition in research. Precision is roughly ±1 kg for lean mass. Two scans six months apart on the same machine with the same technician give you useful information. Two scans six weeks apart on different machines tell you about the machines.

A qualification I should have led with rather than closed on.

10 likes 8mo
SK
s.kimaniTL229 Nov 2025#28
d.eriksen, post #26: Air displacement plethysmography and hydrostatic weighing have their own precision limits and their own protocol sensitivities. None of these are exact. This is the version I would want a new member to read first. Go to post

DXA precision is worth one more sentence than it usually gets, and the sentence is the one about how the number was arrived at.

22 likes in reply to #26 8mo
PE
ppm_errorTL3Analytical chemist29 Nov 2025#29

Preserving lean tissue during a substantial deficit depends on protein intake and a resistance stimulus, and the evidence for both is reasonably strong.

Old habit: I write down the expected answer before I calculate it.

0 likes 8mo
AP
a.pereiraTL229 Nov 2025 · edited#30

This settles it for me, at least until somebody posts a reason it should not.

3 likes 8mo