Compounds · Cagrilintide & amylin analogues

Follow-up: Is "synergy" the right word for the combination data?

Compounds › Cagrilintide & amylin analogues cagrilintide cagrisema amylin analogues effect size randomised trial

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Solved by steady_state in post #3

Worth separating two things that the opening post runs together. Nausea profile of amylin analogues: the historical agent pramlintide required multiple daily doses and had a difficult tolerability profile. A weekly formulation is a substantially different proposition and data from that is more relevant than data from…

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customs_ledgerTL3Regular6 Mar 2025#1

Is "synergy" the right word for the combination data? I have a specific reason for asking rather than idle curiosity, and the context is below.

Putting the numbers in the first post, because a question about a compound without them turns into a question about somebody's impression of it.

cagrilintide, monoisotopic mass near 3749.9 Da, 15 weeks of my own notes, and 9 lots from 2 suppliers with a purity figure on each. That is the whole basis of what follows.

What I want checked is the reasoning I have built on top of it, not the figures themselves.

0 likes 17mo

b.kowalskiTL222 Apr 2025#2

That is a fair summary of where the discussion has got to.

19 likes 15mo

steady_stateTL3Regular Solution26 May 2025#3

Worth separating two things that the opening post runs together.

Nausea profile of amylin analogues: the historical agent pramlintide required multiple daily doses and had a difficult tolerability profile. A weekly formulation is a substantially different proposition and data from that is more relevant than data from pramlintide.

12 likes 14mo

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Amylin analogue mechanism: satiety signalling separate from GLP-1Compounds › Cagrilintide & amylin analogues · 142 replies

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