Practice · Interactions · continued

Follow-up: Oral contraceptives and delayed emptying: what the data shows posts 31–36

Practice › Interactions hypoglycaemia delayed gastric emptying needs a source Closed

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

cannula_notesTL2Member18 Dec 2024 · edited#31

y.adeyemi, post #20: Helpful, and short, which on this subject is harder than long. Go to post

Delayed gastric emptying is the mechanism behind most of the plausible interactions in this class: anything whose absorption depends on how quickly the stomach empties can behave differently.

0 likes in reply to #20 19mo

b.brandtTL223 Dec 2024#32

Post #28 describes the usual case. This is about the unusual one.

The practical advice most consistently given by pharmacists here is to keep the timing of other oral medication consistent rather than to change it, because consistency is what makes a problem visible.

0 likes 19mo

MSaarinenTL3Regular28 Dec 2024#33

Posting my Oral contraceptives and delayed emptying numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by someone who wanted a particular answer.

7 likes 19mo

t.lindqvistTL23 Jan 2025#34

Oral contraceptives and delayed emptying: I have looked for the primary source twice and failed twice. Either it does not exist or it is somewhere I do not know to look, and I would like to know which.

17 likes 19mo

j.delacroixTL3Regular8 Jan 2025#35

The arithmetic in post #34 is right; the assumption feeding it is the part to check.

Oral medications with a narrow therapeutic index are the ones where that matters most. The interaction is about rate and timing rather than about the total absorbed, in most published cases.

25 likes 19mo

i.brobergTL213 Jan 2025#36

Answering the question post #32 raises rather than the one it answers.

SGLT2 inhibitors: frequently co-administered and relevant to renal and cardiovascular discussion, not to interactions. There is no pharmacokinetic interaction of concern.

I have kept the units in throughout, for the obvious reason.

0 likes 18mo

This topic was closed 45 days after the last reply. Closing is automatic for quiet topics so that a settled answer does not collect new questions underneath it. If you have a follow-up, open a new topic and link back to this one — that keeps both readable and gives your question its own title.

Suggested topics

Topic	Participants	Replies	Views	Activity
Follow-up: Reading an interaction checker output critically Practice › Interactions insulin hypoglycaemia delayed gastric emptying needs a source Solved Reading an interaction checker output critically — setting out what I have, and where I think it stops being reliable. A follow-up question about Reading an interaction checker output that I did not know to…	+62	66	13k	2d
Metformin co-administration and additive GI effects Practice › Interactions insulin hypoglycaemia metformin delayed gastric emptying Metformin co-administration and additive GI effects Writing it up because I had to work it out twice and would rather nobody else did. Trying to work out what would count as evidence on metformin…	+28	32	2.1k	15mo
A widely repeated interaction claim that turns out to be unsupported — what changed since Practice › Interactions insulin hypoglycaemia metformin needs a source Solved A widely repeated interaction claim that turns out to be unsupported — what changed since Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about widely repeated…	+89	94	5.9k	2h
Anaesthesia and elective surgery: the aspiration question Practice › Interactions metformin insulin delayed gastric emptying hypoglycaemia Posting this under the heading it deserves: Anaesthesia and elective surgery: the aspiration question Everything below is what sits behind that. A narrow question about anaesthesia and elective surgery,…	+103	115	6.6k	3mo
Antibiotics and a course of something with delayed emptying Practice › Interactions insulin hypoglycaemia needs a source metformin Antibiotics and a course of something with delayed emptying — setting out what I have, and where I think it stops being reliable. Something about antibiotics does not reconcile and I would like a second pair…	+99	108	1.4k	12mo

Related topics — sharing the tags hypoglycaemia, delayed gastric emptying, needs a source

Topic	Participants	Replies	Views	Activity
Pregnancy as an absolute contraindication Safety › Contraindications disordered eating delayed gastric emptying pregnancy & planning pancreatitis Solved Pregnancy as an absolute contraindication — setting out what I have, and where I think it stops being reliable. Pregnancy keeps being re-asked here and I think that is because the answer is conditional and…	+102	106	21k	14mo
Revisiting: Absolute versus relative contraindications Safety › Contraindications disordered eating pregnancy & planning pancreatitis delayed gastric emptying Revisiting: Absolute versus relative contraindications Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about Absolute versus relative contraindications in a…	+11	15	22k	5mo
Constipation management, with a dietitian's contribution Practice › Side effects constipation nausea delayed gastric emptying vomiting Solved Posting this under the heading it deserves: Constipation management, with a dietitian's contribution Everything below is what sits behind that. Constipation management: setting out the arithmetic in full,…	+79	88	27k	21d
Pregnancy as an absolute contraindication — the long version Safety › Contraindications disordered eating pregnancy & planning delayed gastric emptying Under review On the subject in the title: Pregnancy as an absolute contraindication — the long version Working notes rather than a conclusion. A narrow question about Pregnancy, deliberately narrow, because the broad…		2	5.3k	14mo
Revisiting: Absolute versus relative contraindications Safety › Contraindications disordered eating delayed gastric emptying thyroid C-cell question pancreatitis Revisiting: Absolute versus relative contraindications — setting out what I have, and where I think it stops being reliable. A narrow question about Absolute versus relative contraindications, deliberately…	+80	85	7.4k	3mo