The Peptide CommonsEst. May 2024
Independent. We sell nothing and are affiliated with no manufacturer or pharmacy. Every moderation action is logged in public
Devices · Syringes & needles

Gauge and length selection for subcutaneous injection

Solved
Solved by a.lindholm in post #6
Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum. Noting that I have skin in this question and have tried to discount for it.

Jump to the accepted answer →

NV
n.vogelTL221 May 2025#1

Gauge and length selection for subcutaneous injection Writing it up because I had to work it out twice and would rather nobody else did.

A follow-up question about gauge and length selection that I did not know to ask the first time.

The earlier thread answered what I asked. What I should have asked is below, and I think it is the one that matters.

41 likes 14mo
AR
a.reyesTL4 Admin30 May 2025#2

Adding the measurement that the opening post says would settle it.

Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice.

This is the version I would want a new member to read first.

10 likes 14mo
NS
n.silvaTL25 Jun 2025#3

Careful with the language on gauge and length selection. "Not detected" and "not present" are different findings and the first is a statement about the method.

1 like 14mo
OB
owen.bradyTL4 Moderator10 Jun 2025 · edited#4
n.vogel, post #1: Gauge and length selection for subcutaneous injection Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about gauge and length selection that I did not know to ask the first time. The earlier thread answered what I asked. What I should have asked is below, and I think it is the one… Go to post

Gauge and length selection: I have looked for the primary source twice and failed twice. Either it does not exist or it is somewhere I do not know to look, and I would like to know which.

0 likes in reply to #1 14mo
HM
h.mbekiTL215 Jun 2025#5
owen.brady, post #4: Gauge and length selection: I have looked for the primary source twice and failed twice. Either it does not exist or it is somewhere I do not know to look, and I would like to know which. Go to post

This is the answer, and the reason it is the answer is the more useful part.

30 likes in reply to #4 13mo
AL
a.lindholmTL2 Solution20 Jun 2025#6

Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum.

Noting that I have skin in this question and have tried to discount for it.

15 likes 13mo
BO
b.oseiTL224 Jun 2025#7
KR
k.radichTL229 Jun 2025#8
a.reyes, post #2: Adding the measurement that the opening post says would settle it. Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard… Go to post

Confirming post #6 from a second method, which matters more than confirming it from a second person.

Adding a small correction to the gauge and length selection summary above rather than a disagreement with it. The substance holds; one of the figures is out by a factor that matters.

0 likes in reply to #2 13mo
RB
r.bruunTL23 Jul 2025#9
b.osei, post #7: What I want from this gauge and length selection thread is the list of things that would need to be true for the claim to hold. If we can write that list, we can check it. Go to post

U-100 means the barrel is graduated for a solution containing one hundred units of insulin per millilitre. For anything that is not insulin, the units are simply hundredths of a millilitre.

The variance between people here is larger than the effect being discussed.

10 likes in reply to #7 13mo
SC
sourced_claimsTL3Regular7 Jul 2025#10

On gauge and length selection, I would rather understate and be corrected upward than overstate and be quoted. That is a house style here and it is a good one.

3 likes 13mo
ET
e.tammTL211 Jul 2025#11

Confirming post #10 from a second method, which matters more than confirming it from a second person.

Gauge is the outside diameter and higher numbers are thinner. Thinner needles hurt less and draw more slowly, which is the entire trade.

It cost nothing to check and would have cost something not to.

0 likes 13mo
CN
cannula_notesTL2Member15 Jul 2025#12

Gauge and length selection is a good example of a question where the honest answer is boring and the interesting answers are unsupported. I would go with boring.

1 like 12mo
EK
e.krastevTL219 Jul 2025 · edited#13

The thing about gauge and length selection that took me longest to accept is that a plausible mechanism is not evidence of an effect. It is a reason to look, not a result.

11 likes 12mo
M
MSaarinenTL3Regular23 Jul 2025#14
h.mbeki, post #5: This is the answer, and the reason it is the answer is the more useful part. Go to post

Post #12 describes the usual case. This is about the unusual one.

U-100 means the barrel is graduated for a solution containing one hundred units of insulin per millilitre. For anything that is not insulin, the units are simply hundredths of a millilitre.

23 likes in reply to #5 12mo
RO
r.oyelaranTL227 Jul 2025#15

Post #14 is the version of this I will quote in future. One addition.

Whatever the answer on gauge and length selection turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, invite the correction.

0 likes 12mo
RT
r.torrenceTL2Member30 Jul 2025#16

Where I part company with post #12, and it is a narrow parting.

Silicone coating on the barrel affects how smoothly the plunger moves and how a very slow injection feels. It is one reason two syringes at the same specification are not identical to use.

A partial answer, offered because a partial answer beats none.

3 likes 12mo
ZN
z.nakamuraTL23 Aug 2025#17
n.vogel, post #1: Gauge and length selection for subcutaneous injection Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about gauge and length selection that I did not know to ask the first time. The earlier thread answered what I asked. What I should have asked is below, and I think it is the one… Go to post

Fine by me. I had wanted a stronger conclusion and there is not one available.

16 likes in reply to #1 12mo
EM
e.mikkelsenTL26 Aug 2025#18
EK
e.kuipersTL210 Aug 2025#19
r.torrence, post #16: Where I part company with post #12, and it is a narrow parting. Silicone coating on the barrel affects how smoothly the plunger moves and how a very slow injection feels. It is one reason two syringes at the same specification are not identical to use. A partial answer, offered because a partial answer beats none. Go to post

Two questions I would want answered before drawing anything from the gauge and length selection data above: how were the cases selected, and what happened to the ones that dropped out.

1 like in reply to #16 12mo
LM
lyophil_marginTL3Regular13 Aug 2025#20

Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum.

6 likes 11mo
NT
n.torrenceTL3Regular17 Aug 2025#21

Answering the question post #19 raises rather than the one it answers.

Needle length for subcutaneous delivery is a question about tissue depth and injection angle together. Short needles at ninety degrees and longer ones at an angle reach comparable depths.

0 likes 11mo
MA
mi.almeidaTL220 Aug 2025#22

Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum.

31 likes 11mo
V
VThorvaldsenTL3Regular24 Aug 2025#23
n.torrence, post #21: Answering the question post #19 raises rather than the one it answers. Needle length for subcutaneous delivery is a question about tissue depth and injection angle together. Short needles at ninety degrees and longer ones at an angle reach comparable depths. Go to post

Adding a null result on gauge and length selection. I looked, carefully, and found nothing, and null results deserve posting precisely because they never are.

16 likes in reply to #21 11mo
IR
i.rasmussenTL227 Aug 2025#24

Gauge and length selection would be much easier to settle if anyone reported the denominator. Almost nobody reports the denominator.

6 likes 11mo
AR
ambient_reviewTL3Regular30 Aug 2025#25

U-100 means the barrel is graduated for a solution containing one hundred units of insulin per millilitre. For anything that is not insulin, the units are simply hundredths of a millilitre.

The short answer was in the first line; everything after is the working.

1 like 11mo
DN
d.nwosuTL23 Sep 2025#26

Reusing a needle blunts it and there is no benefit to offset that. The second injection with the same needle is the one people describe as painful.

The right answer here may simply be that it has not been measured.

0 likes 11mo
SP
s.poulsenTL3Regular6 Sep 2025#27
n.vogel, post #1: Gauge and length selection for subcutaneous injection Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about gauge and length selection that I did not know to ask the first time. The earlier thread answered what I asked. What I should have asked is below, and I think it is the one… Go to post

Same experience here, different supplier, so it is at least not unique to one of them.

22 likes in reply to #1 11mo
AP
a.petrovTL29 Sep 2025 · edited#28
mi.almeida, post #22: Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum. Go to post

Post #25 is the version of this I will quote in future. One addition.

An update on my earlier gauge and length selection post: the pattern held for another six weeks and then stopped, which I did not predict and cannot explain.

10 likes in reply to #22 11mo
PA
p.amankwahTL212 Sep 2025#29

Having read the whole gauge and length selection thread before replying: the question in the first post has not actually been answered yet, and three of us have answered a nearby one instead.

32 likes 10mo
EF
e.ferrariTL215 Sep 2025#30

Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum.

Speaking for myself and not for anyone else who has posted here.

16 likes 10mo