r.bruun

TL2 · Mombasa

Contributes reviews on supplier material. Based in Mombasa.

Joined 7 April 2025 · last posted 1d

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Insurance and replacement policies, compared Replied, post #121 · Sourcing › Logistics · 26 Jul 2026 · 0 likes Anyone deciding whether a delay is a problem should ask what would change if they waited another week. Usually the answer is nothing. I would put a moderate confidence…
Why cagrilintide alone is discussed so much less than in combination — does this still… Replied, post #31 · Compounds › Cagrilintide & amylin analogues · 25 Jul 2026 · 7 likes On post #27 — agreed on the reasoning, with one qualification. Is synergy the right word for the combination data? A phase 2 trial cannot establish whether effects are…
What a regulator's shortage notice actually authorises Replied, post #7 · Sourcing › Regulatory · 12 Jul 2026 · 1 like Narrowing post #4, because the general version has more than one answer. Generic or biosimilar entry depends on patent and exclusivity positions that are…
NHS criteria and how they are applied in practice Replied, post #25 · Regional › UK & Ireland · 10 Jul 2026 · 0 likes NHS criteria has a well-known answer and a correct answer, and the interesting work is establishing that they are the same. Nobody has done that here yet.
Endotoxin and why it is a separate question from purity — what changed since Replied, post #71 · Analytics › Impurities & related substances · 9 Jul 2026 · 0 likes Answering the question post #69 raises rather than the one it answers. Practical experience of Endotoxin, offered as one case with the conditions stated, not as a…
What is genuinely unknown about long-term amylin agonism Replied, post #15 · Compounds › Cagrilintide & amylin analogues · 8 Jul 2026 · 0 likes Reconstitution at higher concentrations is worth avoiding for aggregation-prone material. The published formulation work generally uses lower concentrations than people…
Micro-titration: a disputed topic, argued properly Replied, post #96 · Practice › Dosing & titration · 27 Jun 2026 · 0 likes I had written a reply contradicting post #92 and deleted it. Here is what survived. What I can speak to on micro-titration is narrow, so I will keep it narrow rather…
Restarting after a long gap: what the labelling implies Started this topic · Practice › Dosing & titration · 24 Jun 2026 · 2 likes Posting this under the heading it deserves: Restarting after a long gap: what the labelling implies Everything below is what sits behind that. I have read the…
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #74 · Compounds › Semaglutide · 22 Jun 2026 · 15 likes On identity confirmation: a mass close to 4113.6 Da on the intact molecule is consistent with semaglutide and is also consistent with several closely related species.…
Why pulsatile secretion matters for interpreting secretagogue claims Started this topic · Compounds › Secretagogues & GH axis · 17 Jun 2026 · 30 likes Why pulsatile secretion matters for interpreting secretagogue claims — that is the question, and I have not found it answered plainly anywhere I have looked. A…
Micronutrient adequacy at low total intake Replied, post #27 · Nutrition & Training › Protein & intake · 8 Jun 2026 · 7 likes Tracking intake for a week rather than permanently is usually enough to find out whether there is a problem. Permanent tracking has its own costs. Adding this to the…
A certificate whose chromatogram axes do not match its stated method — one year on Replied, post #89 · Sourcing › Red flags · 6 Jun 2026 · 0 likes A certificate that reports a specification in the result column is a documentation defect, and it is a defect people should be able to recognise without it being called…