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How shortages have affected compounding permissions — does this still hold?

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Solved by v.salgado in post #9
Building on post #8 rather than restating it. Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking the regulatory website for shortages gives you advance notice. I checked the source rather than the summary, and they differ.

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BV
bias_varianceTL4Biostatistician6 May 2026#1

How shortages have affected compounding permissions — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked.

Asking about shortages directly, because I have read four threads on it and each answered a slightly different question.

The version I want answered is the narrow one: given the method stated below, is the result within what anyone else has seen? I am not asking what it means yet.

Method, numbers and the two assumptions I am aware of making are below. If the assumptions are wrong that is more useful to me than agreement.

3 likes 3mo
YR
y.ramosTL212 May 2026#2

Shortages is a question about a distribution, not about a value, and treating it as a value is what produces the confident wrong answers.

7 likes 3mo
VK
v.klausenTL3Regular16 May 2026#3

Allocation and rationing: during severe shortages, suppliers might ration allocation to prescribers. Understanding rationing policies from your prescriber matters for planning.

The conclusion is tentative; the arithmetic underneath it is not.

25 likes 2mo
SS
s.solbergTL220 May 2026#4
bias_variance, post #1: How shortages have affected compounding permissions — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about shortages directly, because I have read four threads on it and each answered a slightly different question. The version I want answered is the narrow one: given… Go to post

Coming back to post #2, because the follow-up matters more than the original answer.

Adding a reference point for shortages. Mine is a single case, collected without controls, and I am posting the method alongside it so it can be discounted appropriately.

0 likes in reply to #1 2mo
AS
a.stephanopoulosTL3Regular23 May 2026#5

I have no financial interest in anything named in this thread and I want to say so before I comment on shortages, because it is the sort of subject where it matters.

4 likes 2mo
FP
f.petrovTL226 May 2026#6
s.solberg, post #4: Coming back to post #2, because the follow-up matters more than the original answer. Adding a reference point for shortages. Mine is a single case, collected without controls, and I am posting the method alongside it so it can be discounted appropriately. Go to post

Grateful for the specificity. Vague answers to this question are what sent me looking.

12 likes in reply to #4 2mo
VM
v.milanoviTL3Regular29 May 2026#7

Confirming post #4 from a second method, which matters more than confirming it from a second person.

Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and resuming when supply returns is different from gradually tapering. The two are different decisions.

0 likes 2mo
PF
p.friskTL21 Jun 2026#8

I had written a reply contradicting post #7 and deleted it. Here is what survived.

Compounding during shortages: some jurisdictions allow pharmacy compounding when a marketed product is in shortage. That permission is jurisdiction-specific and time-limited (usually for the duration of the shortage).

0 likes 2mo
VS
v.salgadoTL2 Solution4 Jun 2026#9

Building on post #8 rather than restating it.

Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking the regulatory website for shortages gives you advance notice.

I checked the source rather than the summary, and they differ.

7 likes 2mo
LC
lu.cabreraTL27 Jun 2026#10
p.frisk, post #8: I had written a reply contradicting post #7 and deleted it. Here is what survived. Compounding during shortages: some jurisdictions allow pharmacy compounding when a marketed product is in shortage. That permission is jurisdiction-specific and time-limited (usually for the duration of the shortage). Go to post

Post #7 put the caveat in the right place and I want to underline it.

Patient advocacy during shortages: some advocacy groups advocate for patients during shortages. Knowing who they are and following their communication is useful.

2 likes in reply to #8 2mo
ME
me.eriksenTL29 Jun 2026#11

Thank you — that answers what I came here to find out.

0 likes 2mo
CC
c.correiaTL212 Jun 2026#12
f.petrov, post #6: Grateful for the specificity. Vague answers to this question are what sent me looking. Go to post

Shortage status determines what compounding is permitted in some jurisdictions, which links two questions that otherwise seem unrelated.

This has been discussed before and I could not find the thread, so, again.

22 likes in reply to #6 2mo
RR
r.restrepoTL214 Jun 2026#13

Coming back to post #9, because the follow-up matters more than the original answer.

Shortages end and the notices are updated. Checking the current notice takes a minute and is more reliable than a thread from March.

9 likes 1mo
ML
m.lindqvistTL217 Jun 2026#14
DY
d.yilmazTL219 Jun 2026#15

Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking the regulatory website for shortages gives you advance notice.

Adding a source would improve this post and I do not have one to hand.

0 likes 1mo
AW
a.westergaardTL3Regular22 Jun 2026#16
v.salgado, post #9: Building on post #8 rather than restating it. Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking the regulatory website for shortages gives you advance notice. I checked the source rather than the summary, and they differ. Go to post

Shortage status determines what compounding is permitted in some jurisdictions, which links two questions that otherwise seem unrelated.

Not disagreeing with anyone above, just adding the bit I keep having to look up.

29 likes in reply to #9 1mo
SO
sa.okonkwoTL224 Jun 2026#17

I had written a reply contradicting post #13 and deleted it. Here is what survived.

For anyone finding this later: the short answer on shortages is that it depends on one thing, and the rest of the thread is people identifying which thing.

14 likes 1mo
JD
j.delacroixTL3Regular27 Jun 2026#18

Shortages is one of those subjects where the general answer and the answer for a specific case diverge, and the thread will go in circles until someone says which one is being asked for.

5 likes 1mo
RM
ra.mensaTL229 Jun 2026#19

Reports that a pharmacy has stock are the least durable information on the site and are still worth posting with a date.

23 likes 29d
CW
cohort_watchTL2Member1 Jul 2026#20

Reading rather than contributing, but this is the most useful thread I have found on it.

10 likes 27d
AD
ambient_draftTL33 Jul 2026#21
MA
mi.amankwahTL26 Jul 2026#22

Patient advocacy during shortages: some advocacy groups advocate for patients during shortages. Knowing who they are and following their communication is useful.

0 likes 22d
TS
t.steenkampTL2Member8 Jul 2026#23
mi.amankwah, post #22: Patient advocacy during shortages: some advocacy groups advocate for patients during shortages. Knowing who they are and following their communication is useful. Go to post

Building on post #22 rather than restating it.

Both are useful and different. The notice tells you the national position; the account tells you what is happening on the ground.

6 likes in reply to #22 20d
AK
ak.kravchenkoTL210 Jul 2026#24
a.stephanopoulos, post #5: I have no financial interest in anything named in this thread and I want to say so before I comment on shortages, because it is the sort of subject where it matters. Go to post

Post #22 put the caveat in the right place and I want to underline it.

My experience of shortages contradicts the reply above. I am posting it as a data point rather than as a refutation, because one person's experience is exactly that.

15 likes in reply to #5 18d
BR
buffer_reviewTL3Regular12 Jul 2026#25

Worth separating shortages as a question about the compound from shortages as a question about the documentation. They get answered by different people and only one of them is answerable here.

0 likes 16d
AN
a.norgaardTL215 Jul 2026 · edited#26

Second this, and I would have said it less carefully.

1 like 13d
L
LJankowiakTL3Regular17 Jul 2026#27

Taking post #25 at face value and following it one step further.

Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and resuming when supply returns is different from gradually tapering. The two are different decisions.

That has held every time I have looked, which is not the same as always.

10 likes 11d
AC
a.cardosoTL219 Jul 2026#28
v.salgado, post #9: Building on post #8 rather than restating it. Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking the regulatory website for shortages gives you advance notice. I checked the source rather than the summary, and they differ. Go to post

I would put moderate confidence on the mainstream reading of shortages and no more. That is not scepticism for its own sake; it is where the sourcing actually stops.

22 likes in reply to #9 9d
K
KTurkingtonTL3Regular21 Jul 2026#29

Post #27 is right about the mechanism and I think understates the practical bit.

Compounding during shortages: some jurisdictions allow pharmacy compounding when a marketed product is in shortage. That permission is jurisdiction-specific and time-limited (usually for the duration of the shortage).

It is the sort of thing that seems obvious in retrospect and was not at the time.

0 likes 7d
SB
s.bergstromTL223 Jul 2026#30

Adding the boring version of shortages, because the interesting version keeps getting posted and the boring one is usually right.

Check the ordinary explanations, in order, and stop when one of them accounts for what you are seeing. Most of the time the second one does.

3 likes 5d