I will take the caveat as seriously as the claim, which is the point of putting it there.
26 likes 15mo
Topic summary
Journal club: indirect comparison between two programmes, defended and attacked — one year on
This is a generated summary. It shows the 7 most-liked posts from a topic of 51, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.
figure_review, post #9: Source for the indirect comparison figure, since it was asked for. It is in the discussion rather than the abstract, which is why the version circulating is stronger than the paper is. Reading the surrounding paragraph is worth the two minutes. The authors are more careful than their summarisers. Go to post
A session that ends with a list of what remains unresolved is more useful than one that ends with a verdict. The unresolved list is what feeds the next reading.
I am confident about the direction and much less about the magnitude.
Buchholz, post #16: Picking up post #13: that is the part I would want checked first. Bringing the previous paper on the same question makes the session much better and doubles the preparation. Worth doing every third session rather than every one. Go to post
Indirect comparison is one of those subjects where the general answer and the answer for a specific case diverge, and the thread will go in circles until someone says which one is being asked for.
r.oyelaran, post #8: Reading order that works for these sessions: registry entry, methods, baseline table, primary result, then abstract last. Reading the abstract first anchors everything that follows. Scoping that to what I have actually seen rather than what I have read. Go to post
Posting my indirect comparison numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by someone who wanted a particular answer.
t.kulkarni, post #32: A session that ends with a list of what remains unresolved is more useful than one that ends with a verdict. The unresolved list is what feeds the next reading. If the premise is wrong, everything after it is decoration. Go to post
Confirming post #39 from a second method, which matters more than confirming it from a second person.
The baseline characteristics table is the single most useful page for the questions that get asked here, because it tells you who the result applies to.
That is the practical version. The rigorous version is longer and says the same thing.
m.yildiz, post #6: Sessions on negative or null results are consistently the most instructive and the hardest to get anyone to attend. Go to post
STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most subsequent comparison. Mean weight reduction was substantially larger than anything previously achieved pharmacologically.
Acknowledging rather than arguing. The reasoning holds as far as I can follow it.
31 likes 9mo
Read the full topic (51 posts)
This topic was referenced in
- Journal club: STEP 8 and the fairness of the comparator dose — a second datasetEvidence › Journal club · 22 replies
- [2026 update] Journal club: FLOW and the renal composite, component by componentEvidence › Journal club · 2 replies
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