The Peptide CommonsEst. May 2024
Independent. We sell nothing and are affiliated with no manufacturer or pharmacy. Every moderation action is logged in public
Tags · Evidence

risk of bias

Structured appraisal of internal validity.

83 topics 21 solved Group: Evidence

Related in this group: STEP programme · SURMOUNT programme · SURPASS programme · SELECT trial · FLOW trial · SOUL trial · TRIUMPH programme · PIONEER programme · SUSTAIN programme · LEADER trial · randomised trial · meta-analysis

83 topics · page 1 of 3

TopicParticipantsRepliesViewsActivity
Journal club: indirect comparison between two programmes, defended and attacked
Journal club: indirect comparison between two programmes, defended and attacked Writing it up because I had to work it out twice and would rather nobody else did. Trying to work out what would count as…
BPTTARNSET+122 131 5.2k just now
Journal club: STEP 1 and the treatment-policy estimand
Journal club: STEP 1 and the treatment-policy estimand Writing it up because I had to work it out twice and would rather nobody else did. Session topic: STEP 1 ( N Engl J Med , 2021). Please read it before…
ZNBSRTW 3 11k 9h
Journal club: STEP 8 and the fairness of the comparator dose — a second dataset
Posting this under the heading it deserves: Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Everything below is what sits behind that. Posting a small dataset on STEP 8. It is…
OLIADSRFDO+18 22 656 13h
Journal club: semaglutide in MASH, and surrogate endpoints
Posting this under the heading it deserves: Journal club: semaglutide in MASH, and surrogate endpoints Everything below is what sits behind that. Working notes on semaglutide in MASH rather than a conclusion.…
MDSRSGSLSC+24 28 17k 15h
Journal club: STEP 1 and the treatment-policy estimand — does this still hold?
Asking directly, because I could not find a straight answer: Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Working notes on STEP 1 rather than a conclusion. I would rather…
GKRCDALB+70 76 4.8k 15h
A critique that turned out to be unfair, retracted by its author
Posting this under the heading it deserves: A critique that turned out to be unfair, retracted by its author Everything below is what sits behind that. Critique, and specifically the version of it that the…
MSASFIONS+34 38 20k 17h
Coming back to: A structured critique template this community uses
Posting this under the heading it deserves: A structured critique template this community uses Everything below is what sits behind that. Reading back through what has been written here about structured…
SOFAKHASMY+63 69 17k 18h
Immortal time bias in a claims-database study — one year on
Posting this under the heading it deserves: Immortal time bias in a claims-database study — one year on Everything below is what sits behind that. I would like to disagree carefully with the settled view on…
VMDMMGRPT+41 46 3.7k 22h
Risk-of-bias tools and the judgement they conceal — does this still hold?
Risk-of-bias tools and the judgement they conceal — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about Risk-of-bias tools on behalf of…
GLGEBSR+26 30 5.8k 23h
Pooling trials with different estimands
On the subject in the title: Pooling trials with different estimands Working notes rather than a conclusion. Asking about pooling trials with different estimands on behalf of the question I keep seeing asked…
RCFCTSRMME+120 132 2.3k 1d
A structured critique template this community uses
A structured critique template this community uses — setting out what I have, and where I think it stops being reliable. Structured critique template — I have the observation and I do not trust my…
ZOCEK 2 18k 1d
Selection into a registry and what it does to the estimate — a second dataset
Posting this under the heading it deserves: Selection into a registry and what it does to the estimate — a second dataset Everything below is what sits behind that. Posting a small dataset on Selection. It is…
PBINVFPES+28 32 1.3k 1d
Revisiting: How this community labels and discusses unrefereed work
Revisiting: How this community labels and discusses unrefereed work Writing it up because I had to work it out twice and would rather nobody else did. Reading an unrefereed manuscript properly, and asking…
VBNKEARSI+31 35 7k 1d
Journal club: SUSTAIN 6 and its retinopathy signal
On the subject in the title: Journal club: SUSTAIN 6 and its retinopathy signal Working notes rather than a conclusion. Reading SUSTAIN 6 ( N Engl J Med , 2016) for the population rather than the effect,…
LAMRZHOJI+110 122 46k 1d
Coming back to: Why a preprint's supplementary material is often the best part
Why a preprint's supplementary material is often the best part — that is the question, and I have not found it answered plainly anywhere I have looked. A question about how this site should cite something…
GDIBDTHFBV+109 116 36k 2d
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field — setting out what I have, and where I think it stops being reliable. Collecting what is known about SURMOUNT-OSA in one place,…
FPHMLPAAVB+108 122 52k 7d
Revisiting: Journal club: SURMOUNT-1, read without the press release
On the subject in the title: Revisiting: Journal club: SURMOUNT-1, read without the press release Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it…
PPKFAALMDN+54 62 1.5k 26d
Journal club: STEP 3 and the intensive behavioural therapy floor
Posting this under the heading it deserves: Journal club: STEP 3 and the intensive behavioural therapy floor Everything below is what sits behind that. Two things I would like separated before anyone answers…
LSDOJFPWCL+6 10 13k 28d
Second pass at: A pooled estimate that changed when one trial was added
On the subject in the title: Second pass at: A pooled estimate that changed when one trial was added Working notes rather than a conclusion. Two things I would like separated before anyone answers on pooled…
FLSTYAWNRM+26 30 22k 1mo
Journal club: SELECT, absolute risk, and how it was reported — a second dataset
On the subject in the title: Journal club: SELECT, absolute risk, and how it was reported — a second dataset Working notes rather than a conclusion. Posting a small dataset on SELECT. It is mine, it is…
VKJBFNAITH 4 1.3k 1mo
How this community labels and discusses unrefereed work — the long version
Asking directly, because I could not find a straight answer: How this community labels and discusses unrefereed work — the long version Reading an unrefereed manuscript properly, and asking whether I am doing…
ITLCNBBI+18 23 21k 2mo
About the Preprints category
Unrefereed work, clearly labelled as such, with the usual caveats stated once and taken seriously. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…
JMDONIBSP+3 7 14k 3mo
Publication bias detection and its low power — does this still hold?
The question in the title: Publication bias detection and its low power — does this still hold? I will give what I have already checked below so nobody repeats it. Collecting what is known about Publication…
RCGAKDBSP+24 28 2.4k 3mo
The "under review" status pill and when a moderator applies it
Posting this under the heading it deserves: The "under review" status pill and when a moderator applies it Everything below is what sits behind that. A question about how this site should cite something that…
NLAMDOVRV+96 119 17k 3mo
Coming back to: Measurement error in a self-reported exposure
Measurement error in a self-reported exposure — setting out what I have, and where I think it stops being reliable. Reading back through what has been written here about Measurement error, three questions…
LARNOAKACD+23 27 49k 3mo
Second pass at: What pooling buys you and what it destroys
Posting this under the heading it deserves: Second pass at: What pooling buys you and what it destroys Everything below is what sits behind that. Something about pooling buys does not reconcile and I would…
MHCCYMRMBJ+32 36 19k 4mo
Prediction intervals and why they are more honest than confidence intervals
Posting this under the heading it deserves: Prediction intervals and why they are more honest than confidence intervals Everything below is what sits behind that. I have spent a fortnight trying to pin…
DBWSRMON+21 25 46k 4mo
Preprint servers and what screening they do — the long version
On the subject in the title: Preprint servers and what screening they do — the long version Working notes rather than a conclusion. A preprint question rather than a question about the finding in it. The…
APNEYASSRM+7 11 26k 4mo
Citing a preprint in a maintained document: our rule and its reasoning
On the subject in the title: Citing a preprint in a maintained document: our rule and its reasoning Working notes rather than a conclusion. A preprint question rather than a question about the finding in it.…
OVSLTN 2 467 4mo
Journal club: PIONEER 6 as a safety trial
Posting this under the heading it deserves: Journal club: PIONEER 6 as a safety trial Everything below is what sits behind that. Reading PIONEER 6 ( N Engl J Med , 2019) for the population rather than the…
SCMONMWSH+14 18 262 5mo