Evidence · Journal club · continued

Journal club: STEP 4 and what a withdrawal design can prove — one year on posts 61–63

Evidence › Journal club number needed to treat estimand randomised trial effect size Closed

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

baseline_peakTL2Member24 Apr 2025#61

Where I part company with post #57, and it is a narrow parting.

Bringing the previous paper on the same question makes the session much better and doubles the preparation. Worth doing every third session rather than every one.

0 likes 15mo

b.jansenTL227 Apr 2025#62

Post #61 is the version of this I will quote in future. One addition.

Reframing STEP 4 slightly, because I think the disagreement is about the question rather than the answer. If the question is "does it happen", yes. If it is "how often", nobody here knows.

26 likes 15mo

m.stephanopoulosTL3Regular29 Apr 2025#63

Adding what did not work for me on STEP 4, since the failures never get written up and they are half the useful information.

13 likes 15mo

This topic was referenced in

Journal club: FLOW and the renal composite, component by componentEvidence › Journal club · 91 replies
Journal club: how we handle discontinuation in obesity trialsEvidence › Journal club · 2 replies

This topic was closed 180 days after the last reply. Closing is automatic for quiet topics so that a settled answer does not collect new questions underneath it. If you have a follow-up, open a new topic and link back to this one — that keeps both readable and gives your question its own title.

Moved from Meta-analyses by j.mwangi. Category placement is not obvious from outside and getting it wrong is expected. This topic will get better answers here. The move is recorded in the public log citing R7.

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