A titration plan written down in advance is easier to stick to and easier to abandon deliberately. An improvised one becomes a series of decisions made on the worst day of each week.
Take the reasoning and check the arithmetic; I do not always get it right.
The four-week step is a trial convention, not a pharmacological constant. It is roughly four half-lives for a week-long half-life, which is the interval at which you are assessing a stable concentration rather than a rising one.
Scoping that to what I have actually seen rather than what I have read.
Reaching a dose and staying there for a year: the question of whether a stable dose remains effective over years is mostly answered by the withdrawal trials and by real-world reports. The dose does not seem to stop working, but the longest trials are not indefinitely long.
Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.
That is the practical version. The rigorous version is longer and says the same thing.
I think the Micro-titration question is answerable and has not been answered, which is a more optimistic position than most of this thread.
Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.
Everything in post #53 holds. The case it does not cover is the one I have.
Micro-titration has a well-known answer and a correct answer, and the interesting work is establishing that they are the same. Nobody has done that here yet.
Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.
Read the full topic (69 posts)
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