Obstructive sleep apnoea and a hard endpoint in this class

On the subject in the title: Obstructive sleep apnoea and a hard endpoint in this class Working notes rather than a conclusion.

I was wrong about obstructive sleep apnoea in a thread last spring and I would like to correct it publicly rather than quietly.

The error was in the units, which changed the conclusion by an order of magnitude. Setting out the corrected version, and the way I now check for that class of mistake.

Reading back through, this was answered upthread and I missed it. My fault.

Practical note on obstructive sleep apnoea: write down what you expect before you look. The number of times I have found what I went looking for is higher than chance would allow.

Careful with the language on obstructive sleep apnoea. "Not detected" and "not present" are different findings and the first is a statement about the method.

An honest declaration on obstructive sleep apnoea: I have a prior here and it is strong enough that you should weight what I say downward. Stating it rather than hiding it.

Where the honest answer is "nobody knows", giving it plainly is more useful than a confident synthesis of mechanism and anecdote.

Comorbidity control: if a comorbidity (high blood pressure, high lipids) is not adequately controlled, the decision about adding compounds in this class depends on the current control status, not on the compound alone.

Happy to be corrected if someone holds better data than mine.

Narrowing post #114, because the general version has more than one answer.

One caution on obstructive sleep apnoea: everything above assumes the underlying documentation is what it claims to be. That assumption is doing real work and is rarely stated.

Obstructive sleep apnoea sits at the boundary between what this community can usefully discuss and what it cannot, and I think it falls on the discussable side, narrowly.