Osteoarthritis and mechanical versus metabolic improvement — one year on

Answering the question post #4 raises rather than the one it answers.

Post-authorisation safety studies are the place where under-studied populations eventually appear, and they are public.

I have said this before in a thread nobody could find, so it is worth repeating.

Nothing here is medical advice and clinicians posting in this subcategory say so on their own account rather than because a rule requires it.

The failure mode on Osteoarthritis and mechanical versus metabolic is boring rather than dramatic. It is almost always the step everyone assumes was done correctly because it is too simple to get wrong.

The most common failure in this subcategory is answering a specific person's question as though it were the general one. They deserve different answers.

The rule of thumb is fine; the edge cases are where it earns its keep.

Gastrointestinal conditions interact with a mechanism that slows gastric emptying in ways that are plausible and largely unstudied.

Happy to be the one who is wrong here if it settles the question.

Post #33 describes the usual case. This is about the unusual one.

Bariatric surgery history: altered anatomy after surgery affects absorption. That matters for oral medications and for reconstituted solutions. Discussing specific medications and doses with a clinician familiar with bariatric surgery is prudent.

Posting it because the silence on this was starting to look like agreement.

Gastrointestinal conditions interact with a mechanism that slows gastric emptying in ways that are plausible and largely unstudied.

Taking post #51 at face value and following it one step further.

Answering the Osteoarthritis and mechanical versus metabolic question as asked, then the question I think is meant. As asked: yes, with the qualification below. As meant: it depends on how the first measurement was taken.