Analytics · COA interpretation · continued

Second pass at: Certificates issued by the seller versus by a laboratory posts 91–93

Analytics › COA interpretation certificate of analysis amino acid analysis batch & lot numbers

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

b.fonsecaTL231 Jan 2025#91

A chromatogram supplied as a small image is legible for peak shape and not for baseline detail. That is enough to sanity-check an integration and not enough to reproduce it.

17 likes 18mo

a.adebayoTL231 Jan 2025#92

n.abernathy, post #33: An itemised related-substances table with retention times says considerably more about the synthesis than a single total. A total tells you how much is not the main peak and nothing about what it is. Go to post

The distinction between release testing and characterisation is one industrial documents make and retail ones usually do not. It is the difference between "we tested every lot for this" and "we established this once".

The literature is thinner on this than the confidence in the thread implies.

32 likes in reply to #33 18mo

a.zamoraTL231 Jan 2025#93

Post #92 is the version of this I will quote in future. One addition.

An itemised related-substances table with retention times says considerably more about the synthesis than a single total. A total tells you how much is not the main peak and nothing about what it is.

I would rather be precise about what I do not know than vague about what I do.

0 likes 18mo

This topic was referenced in

A checklist for reading a certificate in under two minutes — does this still hold?Analytics › COA interpretation · 55 replies

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