Topic summary

Second pass at: Historical amylin analogues and what happened to them

Compounds › Cagrilintide & amylin analogues amylin analogues effect size cagrilintide cagrisema randomised trial Closed

This is a generated summary. It shows the 5 most-liked posts from a topic of 20, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

BirkelandTL3Regular5 Jan 2025#4

citation_index, post #2: What would change my mind on Historical amylin analogues is a second dataset collected by someone with no stake in the first. Until then I hold it loosely and I would rather say so than pretend to more. Go to post

Post #3 answers the question as asked. The question underneath it is different.

Amylin signalling is distinct from GLP-1 signalling. Amylin slows gastric emptying and promotes satiety through a different receptor and different neural pathways. The hypothesis behind combination is two complementary satiety mechanisms with one injection.

That is my reading. Someone else read the same page differently and was reasonable.

19 likes in reply to #2 19mo

ar.kravchenkoTL29 Jan 2025#7

On analysis: an amylin analogue and its aggregates are not equally detectable by a standard reversed-phase method, because a large aggregate may not elute at all. Area percent cannot see what stays on the column.

27 likes 19mo

r.vukovicTL216 Jan 2025#13

ar.kravchenko, post #7: On analysis: an amylin analogue and its aggregates are not equally detectable by a standard reversed-phase method, because a large aggregate may not elute at all. Area percent cannot see what stays on the column. Go to post

What is genuinely unknown about long-term amylin agonism: real-world response rates, whether effect is durable with continued use, whether satiety adaptation occurs over months or years, safety profile in populations not enrolled in the trials.

Filing this under things that are true until someone shows me otherwise.

17 likes in reply to #7 18mo

r.mcalisterTL3Regular17 Jan 2025#14

r.nakamura, post #11: Native amylin has awkward physical properties — it aggregates readily, which is why a stable analogue is a pharmaceutical achievement rather than a formulation detail. Go to post

Post #10 and I disagree about the size of the effect, not about the direction.

Practical experience of Historical amylin analogues, offered as one case with the conditions stated, not as a general finding. Conditions first, because they are what make it interpretable.

32 likes in reply to #11 18mo

k.otieno_statsTL3Statistician21 Jan 2025#18

tracked_parcel, post #16: Nausea profile of amylin analogues: the historical agent pramlintide required multiple daily doses and had a difficult tolerability profile. A weekly formulation is a substantially different proposition and data from that is more relevant than data from pramlintide. I would treat that as a working assumption and revisit it. Go to post

That is consistent with mine, for whatever one more account is worth.

24 likes in reply to #16 18mo

Read the full topic (20 posts)

This topic was referenced in

The CagriSema phase 2 paper and what a fixed combination buys — the long versionCompounds › Cagrilintide & amylin analogues · 158 replies

This topic was closed 180 days after the last reply. Closing is automatic for quiet topics so that a settled answer does not collect new questions underneath it. If you have a follow-up, open a new topic and link back to this one — that keeps both readable and gives your question its own title.

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