TB-500 and thymosin beta-4: the fragment versus the protein — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked.
Two things I would like separated before anyone answers on TB-500 and thymosin beta-4, because they get bundled and then argued about as one thing.
The first is descriptive: what has actually been observed, by whom, and how. The second is causal: why. I am asking about the first only.
Where I part company with post #2, and it is a narrow parting.
Two questions I would want answered before drawing anything from the TB-500 and thymosin beta-4 data above: how were the cases selected, and what happened to the ones that dropped out.
Post #13 is right about the mechanism and I think understates the practical bit.
The lyophilised cake is worth looking at before adding diluent. A collapsed or shrunken cake is not a purity finding but it does say something about how the vial was made and how it travelled.
That is a description of practice, not a recommendation of it.
Building on post #17 rather than restating it.
Where I have landed on TB-500 and thymosin beta-4, having got it wrong once in public: the direction is clear, the magnitude is not, and anyone quoting a precise magnitude has borrowed it from somewhere that did not measure it.
This is the answer, and the reason it is the answer is the more useful part.
Read the full topic (24 posts)
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