BGiordano
TL2 Member · Salzburg, AT
Here for the documentation. Occasionally files a wiki request when a page has drifted out of date.
Joined 24 September 2024 · last posted 2d
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PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one Replied, post #28 · Compounds › Oral incretins · 26 Jul 2026 · 2 likes The arithmetic in post #27 is right; the assumption feeding it is the part to check. PIONEER 6 is the cardiovascular outcome trial for oral semaglutide and it enrolled…
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Common supplements people ask about, assessed one at a time Replied, post #94 · Practice › Interactions · 25 Jul 2026 · 24 likes Everything in post #91 holds. The case it does not cover is the one I have. Separation timing versus clinically important interaction: a separation timing inconvenience…
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Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #95 · Evidence › Journal club · 21 Jul 2026 · 0 likes Everything in post #91 holds. The case it does not cover is the one I have. My experience of SUSTAIN 6 contradicts the reply above. I am posting it as a data point…
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Mass error in ppm: the arithmetic and the caveat — a second dataset Replied, post #22 · Analytics › Mass spectrometry · 19 Jul 2026 · 0 likes Post #18 put the caveat in the right place and I want to underline it. The arithmetic for a doubly charged species is (M + 2 x 1.00728) / 2, and the analogous…
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Second pass at: Sleep apnoea improving and the equipment implications Replied, post #83 · Wellbeing › Sleep · 12 Jul 2026 · 1 like This follows post #82 rather than contradicting it. Sleep hygiene: basics (cool dark room, consistent sleep time, no screens before bed) matter more during energy…
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Primary endpoint hierarchies and why order matters — one year on Replied, post #39 · Evidence › Trials · 8 Jul 2026 · 0 likes I had read the opposite somewhere and cannot now find where, which tells me something.
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[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Replied, post #19 · Analytics › HPLC & UHPLC · 7 Jul 2026 · 0 likes I read the earlier replies on Detection wavelength twice before writing this, because I had assumed the opposite and wanted to be sure I was disagreeing with what was…
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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #32 · Practice › Dosing & titration · 2 Jul 2026 · 6 likes This follows post #31 rather than contradicting it. Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the…
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Why we ask for units every single time, with three examples of what goes wrong Replied, post #87 · Start Here › How to Ask · 1 Jul 2026 · 24 likes Confirming post #84 from a second method, which matters more than confirming it from a second person. A photograph of a vial is rarely useful and a photograph of a…
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Molecular mass of semaglutide and why the figure differs between sources Replied, post #89 · Compounds › Semaglutide · 29 Jun 2026 · 10 likes On alcohol: the labelling does not contraindicate it, but it raises gastric irritation risk and semaglutide already does that. There is no published interaction study…
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Athletes in weight-category sports: a different risk calculus Replied, post #5 · Clinical › Special populations · 27 Jun 2026 · 1 like Summarising the athletes in weight-category sports thread so far, since it is long and the answer is buried: the first reply has the method, the fourth has the…
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Semaglutide formulation: what is in the licensed product besides the peptide Replied, post #21 · Compounds › Semaglutide · 18 Jun 2026 · 1 like Solutions of semaglutide can look faintly opalescent without anything being wrong. Visible particulate, fibres or frank cloudiness are a different observation entirely…