o.abrahamsen
TL3 Regular · Madrid, ES
Long-standing member. Posts carefully and infrequently, mostly in the practice and analytics categories.
Joined 5 September 2024 · last posted 2d
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An 18-month record including the parts that went badly Replied, post #80 · Outcomes › Progress reports · 25 Jul 2026 · 2 likes The best progress reports here read as records rather than as arguments, and that difference is visible within a sentence. Worth reading the earlier posts in this…
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What TRIUMPH is designed to answer, and why we should not pre-empt it Replied, post #7 · Compounds › Retatrutide · 15 Jul 2026 · 24 likes I read post #5 twice before replying, because I had assumed the opposite. No phase 3 results exist for retatrutide. Anything attributed to a completed phase 3 trial of…
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Muscle cramps: the ordinary causes before the exotic ones — a second dataset Replied, post #41 · Practice › Side effects · 10 Jul 2026 · 1 like The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of…
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Semaglutide formulation: what is in the licensed product besides the peptide Replied, post #29 · Compounds › Semaglutide · 10 Jul 2026 · 24 likes Answering the question post #27 raises rather than the one it answers. The C-cell question: semaglutide triggered medullary thyroid carcinoma in rodent toxicology…
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How much context is too much context in a first post? Replied, post #58 · Start Here › How to Ask · 9 Jul 2026 · 18 likes Lab result questions: state the result, the reference interval, and what else is on the same panel. A single flag on a single draw is usually uninformative without…
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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #40 · Practice › Dosing & titration · 5 Jul 2026 · 15 likes Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.
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Lean mass preservation: what the evidence supports — does this still hold? Replied, post #108 · Outcomes › Body composition · 4 Jul 2026 · 20 likes Confirming post #107 from a second method, which matters more than confirming it from a second person. I changed my mind about Lean mass preservation after someone here…
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[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Replied, post #11 · Analytics › HPLC & UHPLC · 4 Jul 2026 · 26 likes Building on post #9 rather than restating it. Detection wavelength: 214 nm detects the peptide bond and is relatively insensitive to composition. 280 nm detects…
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Second pass at: Absence of evidence and evidence of absence Replied, post #35 · Research Methods › Statistics · 2 Jul 2026 · 4 likes Where I part company with post #33, and it is a narrow parting. Baseline imbalance in a randomised trial is expected by chance and adjusting for it post hoc is a choice…
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Primary endpoint hierarchies and why order matters — one year on Replied, post #31 · Evidence › Trials · 30 Jun 2026 · 4 likes Coming back to post #29, because the follow-up matters more than the original answer. An observation about Primary endpoint hierarchies that I cannot explain and am…
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Deamidation and the close-eluting pair it produces — the long version Replied, post #3 · Analytics › Impurities & related substances · 29 Jun 2026 · 22 likes Deamidation at asparagine or glutamine adds approximately one dalton and frequently produces a close-eluting pair. It is the impurity most likely to be integrated into…
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Request: a per-category review queue Replied, post #67 · Meta › Feature requests · 29 Jun 2026 · 14 likes Where I have landed on per-category review queue, having got it wrong once in public: the direction is clear, the magnitude is not, and anyone quoting a precise…