orbitrap_ola
TL3 Mass spectrometrist · Tampere, FI
High-resolution MS on biologics. Interested in deamidation, oxidation, and what actually shows up as a related substance.
Joined 24 December 2024 · last posted 14h · groups: analytical-chemists, newcomer-guides
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Talking to a therapist about this specifically Replied, post #25 · Wellbeing › Mental health · 27 Jul 2026 · 2 likes Post #22 is right about the mechanism and I think understates the practical bit. Maintenance brings a different set of psychological questions from loss, and the…
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Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #118 · Evidence › Journal club · 26 Jul 2026 · 0 likes I keep a log for SUSTAIN 6 specifically because my memory of it turned out to be systematically wrong in one direction. Six weeks of notes cost nothing and settled it.
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Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #60 · Practice › Interactions · 23 Jul 2026 · 0 likes I have been on both sides of the Delayed gastric emptying and oral argument in this category within eighteen months, which should tell you how strong the evidence for…
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Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #115 · Compounds › Semaglutide · 21 Jul 2026 · 3 likes No notes. Posting so the count is not one.
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[2026 update] Antibiotics and a course of something with delayed emptying Replied, post #68 · Practice › Interactions · 20 Jul 2026 · 0 likes A pharmacist can answer most questions in this subcategory in a few minutes with access to a proper interaction database, and that access is the thing a forum does not…
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Pooling trials with different estimands Replied, post #113 · Evidence › Meta-analyses · 20 Jul 2026 · 0 likes Adding the measurement that post #111 says would settle it. The thing about pooling trials with different estimands that took me longest to accept is that a plausible…
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A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #132 · Practice › Reconstitution · 19 Jul 2026 · 7 likes Swirling until fully clear before drawing is worth the extra minute. A partially dissolved preparation is not uniform and the first dose out of it is not the same as…
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Molecular mass of semaglutide and why the figure differs between sources Replied, post #102 · Compounds › Semaglutide · 16 Jul 2026 · 2 likes That reframing is the whole thing. The facts I already had.
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #81 · Analytics › Impurities & related substances · 16 Jul 2026 · 33 likes Everything in post #77 holds. The case it does not cover is the one I have. Reporting thresholds matter: below a stated threshold, peaks are usually not reported at…
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Receptor desensitisation as a tolerance hypothesis, and its weak evidence Replied, post #44 · Pharmacology › Receptor biology · 14 Jul 2026 · 2 likes Biased agonism — where different ligands at the same receptor favour different downstream pathways — is a plausible explanation for differences between compounds in…
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The anatomy of a question that gets answered within an hour — does this still hold? Replied, post #21 · Start Here › How to Ask · 13 Jul 2026 · 2 likes If the answer you got does not fit your case, say which part does not fit rather than restating the question. Otherwise the next reply is the same as the last one. It…
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Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #49 · Evidence › Journal club · 11 Jul 2026 · 0 likes Post #47 is the version of this I will quote in future. One addition. The most common failure mode is spending fifty minutes on the effect size and ten on the…
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- LC-MS identity confirmationReview due 23 Mar 2027