This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1 · go to the accepted answer.
This follows post #28 rather than contradicting it.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
Speaking for myself and not for anyone else who has posted here.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
Someone should write this up properly, and it should probably not be me.
Post #35 and I disagree about the size of the effect, not about the direction.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
Take it as a starting point and not as a specification.
Narrowing post #36, because the general version has more than one answer.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
On post #39 — agreed on the reasoning, with one qualification.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
It is one reading of the data and not the only reasonable one.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
Post #43 is right about the mechanism and I think understates the practical bit.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
Small point, but it is the one that usually catches people.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
I had written a reply contradicting post #43 and deleted it. Here is what survived.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
If that reads as pedantic, it is, and it has saved me twice.
Confirming post #47 from a second method, which matters more than confirming it from a second person.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
A modest claim, modestly supported.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
Reading it back, the second half matters more than the first.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
Where I part company with post #53, and it is a narrow parting.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
This is the sort of thing that ought to be settled and apparently is not.
I had written a reply contradicting post #56 and deleted it. Here is what survived.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
Two sources, same conclusion, and I could not rule out that one copied the other.
Temperature excursions in transit are common and are not all equal. A few hours warm is a different event from three days warm, and neither is visible in the vial on arrival.
Adding this to the thread rather than to the wiki, because I am not confident enough for the wiki.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.