A parcel that arrived warm: a decision process, not a verdict posts 91–120
This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1 · go to the accepted answer.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
A partial answer, offered because a partial answer beats none.
Worth separating two things that post #92 runs together.
Temperature excursions in transit are common and are not all equal. A few hours warm is a different event from three days warm, and neither is visible in the vial on arrival.
It is worth stating the boring hypothesis before the interesting one.
Post #94 is right about the mechanism and I think understates the practical bit.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
I am confident about the direction and much less about the magnitude.
Coming back to post #92, because the follow-up matters more than the original answer.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
Right, and stated more narrowly than I would have dared to state it.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
Caveat: everything above assumes the paperwork is what it says it is.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
Genuinely open to being wrong about this one.
Collapsed as off-topic by two members at trust level 3 or above
Adding the measurement that post #100 says would settle it.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
Post #98 describes the usual case. This is about the unusual one.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
Adding a source would improve this post and I do not have one to hand.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
Not the answer, but possibly the question that gets there.
Good question, well framed, and I would like to see it answered properly.
Confirming post #104 from a second method, which matters more than confirming it from a second person.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
Collapsed as off-topic by two members at trust level 3 or above
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
The interesting part of this is the exception, and I do not understand the exception.
I came in to disagree and I am leaving without a disagreement.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
I would call that likely rather than established.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
None of the above is medical advice and I am not qualified to give any.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
For what it is worth, the same held on the two occasions I checked.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
That holds for the case as described. Change the assumptions and it may not.
Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
Worth reading the earlier posts in this thread before acting on mine.
Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
If anyone has run this properly I would rather read that than my own guess.