The Peptide CommonsEst. May 2024
Independent. We sell nothing and are affiliated with no manufacturer or pharmacy. Every moderation action is logged in public
Devices · Syringes & needles · continued

A ten-fold dose error caught before injection — one year on posts 61–90

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

LA
l.aaltonenTL3Regular2 Aug 2025 · edited#61
a.vestergaard, post #59: I would call the community position on ten-fold dose error caught likely rather than established, and I would be comfortable defending that hedge. Go to post

The arithmetic in post #60 is right; the assumption feeding it is the part to check.

Barrel size determines resolution and nothing else. A 0.3 mL barrel and a 1 mL barrel deliver the same volume equally well; the smaller one lets you see what you are delivering.

Adding a source would improve this post and I do not have one to hand.

5 likes in reply to #59 12mo
SM
so.mbekiTL22 Aug 2025#62
m.dalgaard, post #12: Barrel size determines resolution and nothing else. A 0.3 mL barrel and a 1 mL barrel deliver the same volume equally well; the smaller one lets you see what you are delivering. Go to post

U-100 means the barrel is graduated for a solution containing one hundred units of insulin per millilitre. For anything that is not insulin, the units are simply hundredths of a millilitre.

Not the answer, but possibly the question that gets there.

13 likes in reply to #12 12mo
W
WickramasingheTL2Member3 Aug 2025#63

Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum.

27 likes 12mo
WM
w.moreauTL23 Aug 2025#64

Post #62 put the caveat in the right place and I want to underline it.

Adding the boring version of ten-fold dose error caught, because the interesting version keeps getting posted and the boring one is usually right.

Check the ordinary explanations, in order, and stop when one of them accounts for what you are seeing. Most of the time the second one does.

0 likes 12mo
N
NLoughranTL3Regular3 Aug 2025#65
ambient_review, post #5: Narrowing post #2, because the general version has more than one answer. Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error. Go to post

Drawing air into the vial before withdrawing liquid equalises the pressure and makes the draw easier. It is not required and it is why some people find a full vial harder to draw from than a half-empty one.

It is one reading of the data and not the only reasonable one.

2 likes in reply to #5 12mo
KK
k.karlsenTL23 Aug 2025#66

Following, with nothing to contribute beyond having asked the same thing elsewhere.

9 likes 12mo
HN
h.nicolaidesTL3Regular3 Aug 2025#67

Taking post #64 at face value and following it one step further.

Barrel size determines resolution and nothing else. A 0.3 mL barrel and a 1 mL barrel deliver the same volume equally well; the smaller one lets you see what you are delivering.

20 likes 12mo
PO
p.onwukaTL23 Aug 2025#68

Post #67 and I disagree about the size of the effect, not about the direction.

Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less.

The interesting part of this is the exception, and I do not understand the exception.

0 likes 12mo
MS
m.stephanopoulosTL3Regular3 Aug 2025#69
Buchholz, post #52: This follows post #51 rather than contradicting it. Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less. On balance I think that is right, and I would not bet much on it. Go to post

Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum.

0 likes in reply to #52 12mo
ZI
z.iyerTL23 Aug 2025 · edited#70

U-100 means the barrel is graduated for a solution containing one hundred units of insulin per millilitre. For anything that is not insulin, the units are simply hundredths of a millilitre.

5 likes 12mo
FF
f.fonsecaTL23 Aug 2025#71

Practical experience of ten-fold dose error caught, offered as one case with the conditions stated, not as a general finding. Conditions first, because they are what make it interpretable.

2 likes 12mo
FW
f.wojcikTL23 Aug 2025#72
s.teixeira, post #19: A detachable luer needle plus hub can retain enough volume to matter. Whether it matters to you depends on your dose, and the arithmetic is worth doing once. Nothing above should be read as advice about what anyone else should do. Go to post

Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error.

0 likes in reply to #19 12mo
SR
s.rasmussenTL23 Aug 2025#73

Everything in post #69 holds. The case it does not cover is the one I have.

Drawing through a wider needle and injecting through a thinner one is a reasonable approach for a viscous preparation and pointless for an aqueous one.

If the premise is wrong, everything after it is decoration.

26 likes 12mo
VB
v.bhattacharyaTL23 Aug 2025#74

Narrowing post #73, because the general version has more than one answer.

Graduation spacing is worth checking before you buy rather than after. Some 1 mL barrels are marked every two units and some every one, and that changes what doses you can read.

Correct me on the arithmetic if it is wrong; I would rather know.

12 likes 12mo
SD
s.duarteTL23 Aug 2025#75

Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are more legible for small doses. Larger barrels hold larger volumes. Choose based on your dose.

0 likes 12mo
AS
a.sorensenTL23 Aug 2025#76
e.mbeki, post #28: One more thing on ten-fold dose error caught that took me far too long to see: the two figures people quote are not measuring the same quantity. Once you notice that, the apparent contradiction disappears. Go to post

Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice.

0 likes in reply to #28 12mo
AS
a.salcedoTL3Regular3 Aug 2025#77

Saving this. It is the version I will quote when the question comes round again.

19 likes 12mo
NN
n.nakamuraTL23 Aug 2025#78

Ten-fold dose error caught was covered in the wiki last year and the page has a review date on it, which is a better starting point than my memory of a thread.

8 likes 12mo
NV
n.villalobosTL23 Aug 2025#79
m.vukovic, post #22: Answering the question post #18 raises rather than the one it answers. Check what the graduations actually say rather than what you expect. A syringe marked in units and one marked in millilitres look similar at a glance and are not the same instrument. Go to post

Buying a box of the wrong barrel size is the most common regret described in this subcategory, and the reason is nearly always that the dose was decided after the syringes.

0 likes in reply to #22 12mo
BI
blank_injectionTL2Analytical chemist3 Aug 2025#80
ambient_review, post #5: Narrowing post #2, because the general version has more than one answer. Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error. Go to post

Post #78 is the version of this I will quote in future. One addition.

Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or 10-12 mm (longer). Longer needles are needed for deeper tissue or if you have abdominal adiposity.

I would hold that lightly until someone with a larger sample weighs in.

27 likes in reply to #5 12mo
GV
g.verhoevenTL23 Aug 2025#81
s.bruun, post #29: Needle length for subcutaneous delivery is a question about tissue depth and injection angle together. Short needles at ninety degrees and longer ones at an angle reach comparable depths. Go to post

This follows post #78 rather than contradicting it.

A detachable luer needle plus hub can retain enough volume to matter. Whether it matters to you depends on your dose, and the arithmetic is worth doing once.

Not disagreeing with anyone above, just adding the bit I keep having to look up.

9 likes in reply to #29 12mo
RS
r.scholtenTL2Member3 Aug 2025#82
cannula_trace, post #48: The thing about ten-fold dose error caught that took me longest to accept is that a plausible mechanism is not evidence of an effect. It is a reason to look, not a result. Go to post

Worth separating two things that post #80 runs together.

Needle length for subcutaneous delivery is a question about tissue depth and injection angle together. Short needles at ninety degrees and longer ones at an angle reach comparable depths.

The uncertainty is in the assumption, not in the calculation.

20 likes in reply to #48 12mo
ON
o.nybergTL23 Aug 2025#83

Adding what did not work for me on ten-fold dose error caught, since the failures never get written up and they are half the useful information.

0 likes 12mo
Z
ZieglerTL3Regular3 Aug 2025#84

That matches what I have seen, for whatever a single anecdote is worth.

2 likes 12mo
ZV
z.vogelTL23 Aug 2025#85
n.nakamura, post #78: Ten-fold dose error caught was covered in the wiki last year and the page has a review date on it, which is a better starting point than my memory of a thread. Go to post

Reusing a needle blunts it and there is no benefit to offset that. The second injection with the same needle is the one people describe as painful.

This has been discussed before and I could not find the thread, so, again.

14 likes in reply to #78 12mo
DW
diluent_watchTL2Member3 Aug 2025#86

On post #85 — agreed on the reasoning, with one qualification.

I have three months of notes on ten-fold dose error caught and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly drew the opposite conclusion from the first fortnight.

28 likes 12mo
CV
ca.vermeulenTL23 Aug 2025#87

Post #86 is right about the mechanism and I think understates the practical bit.

Insulin syringe graduations: U-100 syringes are marked in units where 100 units = 1 mL. Always confirm your syringe is U-100. Confusion between insulin units and milligrams is the most common syringe error.

Reading it again, the caveat matters more than the finding.

0 likes 12mo
W
WoodhouseTL2Member3 Aug 2025 · edited#88

Silicone coating on the barrel affects how smoothly the plunger moves and how a very slow injection feels. It is one reason two syringes at the same specification are not identical to use.

5 likes 12mo
RD
r.danquahTL23 Aug 2025#89
f.espinoza, post #51: Worth separating two things that post #47 runs together. Buying a box of the wrong barrel size is the most common regret described in this subcategory, and the reason is nearly always that the dose was decided after the syringes. Go to post

Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum.

19 likes in reply to #51 12mo
KF
k.fonsecaTL23 Aug 2025#90

If you are new and reading this thread for the answer to ten-fold dose error caught: the answer is conditional, the conditions are in the third reply, and the rest of the thread is worth skipping.

0 likes 12mo