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Sourcing · Independent verification

Blind submission and why it changes minds — the long version

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buffer_reviewTL3Regular26 Mar 2026#1

Posting this under the heading it deserves: Blind submission and why it changes minds — the long version Everything below is what sits behind that.

A narrow question about Blind submission, deliberately narrow, because the broad version has been asked here four times and produced four long threads and no answer.

One question, stated units, stated method, and what I have already ruled out.

0 likes 4mo
IL
integrator_logTL3Regular28 Mar 2026#2

I had written a reply contradicting the opening post and deleted it. Here is what survived.

Where I would push back on the Blind submission consensus is the confidence, not the direction. The direction looks right. The confidence is borrowed.

3 likes 4mo
SS
s.salgadoTL229 Mar 2026 · edited#3

Medutest: combined purity and identity reporting. Appears throughout vendor documentation. Where a submission has been blind we note it because blind results are worth more than self-selected ones.

I would be glad to be shown a cleaner way of putting this.

15 likes 4mo
VT
vial_tableTL2Member30 Mar 2026#4

Blind submission looks different depending on whether you are reading the primary literature or the summaries of it, and the difference is not in our favour.

31 likes 4mo
DV
d.vestergaardTL231 Mar 2026#5
s.salgado, post #3: Medutest: combined purity and identity reporting. Appears throughout vendor documentation. Where a submission has been blind we note it because blind results are worth more than self-selected ones. I would be glad to be shown a cleaner way of putting this. Go to post

Blind submission is worth one more sentence than it usually gets, and the sentence is the one about how the number was arrived at.

0 likes in reply to #3 4mo
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DOdendaalTL3Regular1 Apr 2026#6

Coming back to post #2, because the follow-up matters more than the original answer.

Repeat testing: if you want to verify the same lot a second time, testing with a different service strengthens the conclusion. Testing with the same service verifies reproducibility but uses the same method.

1 like 4mo
CM
c.marchettiTL22 Apr 2026#7

That is a fair summary of where the discussion has got to.

10 likes 4mo
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sterile_fileTL3Regular3 Apr 2026#8

An honest declaration on Blind submission: I have a prior here and it is strong enough that you should weight what I say downward. Stating it rather than hiding it.

23 likes 4mo
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k.asanteTL24 Apr 2026#9

Distinguishing three things in the Blind submission discussion that keep getting used interchangeably: the observation, the proposed mechanism, and the recommendation that gets attached to both.

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crossref_checkTL3Wiki editor5 Apr 2026#10
sterile_file, post #8: An honest declaration on Blind submission: I have a prior here and it is strong enough that you should weight what I say downward. Stating it rather than hiding it. Go to post

Blind sampling: submitting without the laboratory or seller knowing the source removes the two easiest ways for a result to be shaped: selective submission and selective reporting. The extra effort is worth it.

That much is documented. The rest is how I have interpreted it.

0 likes in reply to #8 4mo
RS
r.scholtenTL2Member5 Apr 2026#11
d.vestergaard, post #5: Blind submission is worth one more sentence than it usually gets, and the sentence is the one about how the number was arrived at. Go to post

The version of Blind submission that circulates here is a simplification of a simplification. It is not wrong, but it has lost the conditions under which it holds, and those conditions are where the interesting cases live.

9 likes in reply to #5 4mo
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g.verhoevenTL26 Apr 2026#12

Two people in this thread mean different things by Blind submission and are disagreeing about the definition while believing they are disagreeing about the facts. Worth pausing to define it.

2 likes 4mo
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ZieglerTL3Regular7 Apr 2026#13

Where I part company with post #9, and it is a narrow parting.

It does not extend to lots nobody has seen, it is not a recommendation, and it says nothing about anything other than what was measured.

0 likes 4mo
ON
o.nybergTL28 Apr 2026#14
r.scholten, post #11: The version of Blind submission that circulates here is a simplification of a simplification. It is not wrong, but it has lost the conditions under which it holds, and those conditions are where the interesting cases live. Go to post

Post #13 is the version of this I will quote in future. One addition.

The record shows what was measured. Everything beyond that is inference and this site tries to keep the line visible.

Anyone who has looked at this more carefully, please correct the record.

28 likes in reply to #11 4mo
MD
m.duarteTL29 Apr 2026#15
DOdendaal, post #6: Coming back to post #2, because the follow-up matters more than the original answer. Repeat testing: if you want to verify the same lot a second time, testing with a different service strengthens the conclusion. Testing with the same service verifies reproducibility but uses the same method. Go to post

Post #13 describes the usual case. This is about the unusual one.

Janoshik Analytical: chromatographic purity and mass-spectrometric identity on submitted samples. Reports are issued with the analytical method stated and a chromatogram included. Submission is by mail.

That has held every time I have looked, which is not the same as always.

5 likes in reply to #6 4mo
LA
l.aguirreTL29 Apr 2026#16

Genuine question rather than a rhetorical one: has anyone here actually observed Blind submission, as opposed to read about it? The thread is long and I cannot tell.

0 likes 4mo
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f.fenwickTL310 Apr 2026#17
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ar.petrovTL211 Apr 2026#18

Confirming post #16 from a second method, which matters more than confirming it from a second person.

Repeat determination on the same product line months apart is the measurement that speaks to consistency, and consistency is what most buyers actually want.

20 likes 4mo
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gradient_fileTL2Member11 Apr 2026 · edited#19

Blind submission is well covered in the tag pages, and the older discussions are better than the recent ones because they were argued out properly. Worth twenty minutes before adding to this one.

19 likes 4mo
SK
s.kravchenkoTL212 Apr 2026#20

Picking up post #18: that is the part I would want checked first.

A record with four results over sixteen months is a thin record rather than a bad one, and the honest description says which.

Stating my assumptions rather than smuggling them in.

8 likes 4mo
BV
b.vanheckeTL213 Apr 2026#21
ar.petrov, post #18: Confirming post #16 from a second method, which matters more than confirming it from a second person. Repeat determination on the same product line months apart is the measurement that speaks to consistency, and consistency is what most buyers actually want. Go to post

Post #18 is right about the mechanism and I think understates the practical bit.

My understanding of Blind submission is a few years old and may have been superseded. If it has been, I would genuinely like to know rather than keep repeating it.

1 like in reply to #18 3mo
PE
ppm_errorTL3Analytical chemist13 Apr 2026#22

Coming back to post #20, because the follow-up matters more than the original answer.

Repeat testing: if you want to verify the same lot a second time, testing with a different service strengthens the conclusion. Testing with the same service verifies reproducibility but uses the same method.

I have kept the units in throughout, for the obvious reason.

7 likes 3mo
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d.eriksenTL214 Apr 2026#23
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m.strand_rphTL3Pharmacist15 Apr 2026#24

Blind sampling: submitting without the laboratory or seller knowing the source removes the two easiest ways for a result to be shaped: selective submission and selective reporting. The extra effort is worth it.

0 likes 3mo
SK
s.kimaniTL215 Apr 2026 · edited#25

Two sentences on Blind submission and then I will stop, because the rest is speculation and the thread is better without mine.

What is documented is narrow. What is inferred from it is broad. The gap between them is where every argument here lives.

0 likes 3mo
JM
j.mwangiTL4 Moderator16 Apr 2026#26

I read post #24 twice before replying, because I had assumed the opposite.

Practical experience of Blind submission, offered as one case with the conditions stated, not as a general finding. Conditions first, because they are what make it interpretable.

4 likes 3mo
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n.stanescuTL217 Apr 2026#27

Reading rather than answering, but this is the post I would point somebody at.

18 likes 3mo
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n.haddadTL217 Apr 2026#28
m.duarte, post #15: Post #13 describes the usual case. This is about the unusual one. Janoshik Analytical: chromatographic purity and mass-spectrometric identity on submitted samples. Reports are issued with the analytical method stated and a chromatogram included. Submission is by mail. That has held every time I have looked, which is not the same as… Go to post

Repeat determination on the same product line months apart is the measurement that speaks to consistency, and consistency is what most buyers actually want.

It is a small point and it changes the answer, which is an awkward combination.

0 likes in reply to #15 3mo
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b.petrovTL218 Apr 2026#29

What I would check first on Blind submission is whether the thing being measured moved or whether the way of measuring it moved. Those look identical in a graph.

0 likes 3mo
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j.nwosuTL219 Apr 2026#30

Filing a mild objection to the consensus on Blind submission. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit.

2 likes 3mo