f.fenwick
TL3 Regular · Oporto, PT
Clinician. Posts general information only, and says so every time.
Joined 18 November 2024 · last posted 2d · groups: clinicians
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What a certificate commits its issuer to Replied, post #111 · Analytics › COA interpretation · 26 Jul 2026 · 14 likes On post #107 — agreed on the reasoning, with one qualification. Residual solvent screening is not standard on these documents and its presence is a signal about the…
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #108 · Analytics › Impurities & related substances · 24 Jul 2026 · 21 likes Storage-related degradation and synthesis-related impurity look different on a chromatogram. A growing oxidation peak over time is not a manufacturing finding.
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Here for the analytics and not much else Replied, post #81 · Lounge › Introductions · 23 Jul 2026 · 8 likes Privacy: share only what you are comfortable making permanent and public. An introduction is archived and searchable; do not include information you will later regret…
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[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #115 · Sourcing › Independent verification · 23 Jul 2026 · 4 likes Where two services agree with each other and with the declared figure, that is a genuinely strong result and it applies to that lot.
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About the Mass spectrometry category Replied, post #9 · Analytics › Mass spectrometry · 22 Jul 2026 · 0 likes Second this, and I would have said it less carefully.
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Follow-up: How compounding permissions changed when supply normalised Replied, post #46 · Sourcing › Regulatory · 20 Jul 2026 · 3 likes An honest declaration on compounding permissions: I have a prior here and it is strong enough that you should weight what I say downward. Stating it rather than hiding…
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Primary endpoint hierarchies and why order matters — one year on Replied, post #52 · Evidence › Trials · 19 Jul 2026 · 0 likes The arithmetic in post #51 is right; the assumption feeding it is the part to check. A note on scope: what I am saying about Primary endpoint hierarchies applies to the…
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Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #70 · Evidence › Journal club · 16 Jul 2026 · 7 likes Post #66 and I disagree about the size of the effect, not about the direction. The thing about SUSTAIN 6 that took me longest to accept is that a plausible mechanism is…
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Alcohol: what is documented and what is folklore Replied, post #114 · Practice › Interactions · 16 Jul 2026 · 30 likes Coming back to post #110, because the follow-up matters more than the original answer. Alcohol is not contraindicated in the labelling and it does irritate a stomach…
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Athletes in weight-category sports: a different risk calculus Replied, post #25 · Clinical › Special populations · 14 Jul 2026 · 17 likes Everything in post #23 holds. The case it does not cover is the one I have. Taking athletes in weight-category sports seriously for a moment rather than deflecting: the…
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Coming back to: A community side-effect dataset, with its response rate and biases Replied, post #95 · Data & Tools › Datasets · 13 Jul 2026 · 27 likes Agreed, and I will stop repeating the version of this I had been repeating.
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Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Replied, post #20 · Evidence › Journal club · 12 Jul 2026 · 27 likes Post #17 answers the question as asked. The question underneath it is different. Small methodological point on STEP 8: repeating a measurement is cheap and resolves…