m.duarte

TL2 · Galway

Contributes reviews on supplier material. Based in Galway.

Joined 29 March 2025 · last posted 4d

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Reference intervals: how they are constructed and why one in twenty flags — does this… Replied, post #21 · Clinical › Bloodwork · 24 Jul 2026 · 12 likes Post #20 is right about the mechanism and I think understates the practical bit. Biological variation: the person-to-person variation in a biomarker for a healthy…
Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #106 · Analytics › Impurities & related substances · 23 Jul 2026 · 1 like Post #104 describes the usual case. This is about the unusual one. Oxidation at methionine or tryptophan adds sixteen per oxygen and typically elutes earlier. In aged…
[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #117 · Sourcing › Independent verification · 23 Jul 2026 · 0 likes Taking post #114 at face value and following it one step further. Worth separating Interpreting a result as a question about the compound from Interpreting a result as…
Primary endpoint hierarchies and why order matters — one year on Replied, post #54 · Evidence › Trials · 21 Jul 2026 · 11 likes I think the Primary endpoint hierarchies question is answerable and has not been answered, which is a more optimistic position than most of this thread.
Common supplements people ask about, assessed one at a time Replied, post #36 · Practice › Interactions · 12 Jul 2026 · 22 likes Post #33 describes the usual case. This is about the unusual one. Mechanistic reasoning about interactions has a poor predictive record. It is a good way to generate a…
About the Mass spectrometry category Replied, post #7 · Analytics › Mass spectrometry · 10 Jul 2026 · 31 likes Post #3 and I disagree about the size of the effect, not about the direction. What mass accuracy establishes: the measured mass is consistent with a specific…
Journal club: indirect comparison between two programmes, defended and attacked Replied, post #104 · Evidence › Journal club · 2 Jul 2026 · 2 likes Everything in post #102 holds. The case it does not cover is the one I have. Second-hand on indirect comparison, so weight it accordingly — someone whose method I trust…
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #17 · Compounds › Retatrutide · 28 Jun 2026 · 25 likes The hepatic-steatosis rationale follows directly from glucagon receptor agonism promoting fat oxidation in the liver. Mechanistic plausibility in this field has a poor…
Coming back to: Payment method and the leverage it gives you, ranked Replied, post #10 · Sourcing › Payments · 25 Jun 2026 · 20 likes Fair, and the limits you put on it are the part I will remember.
A pooled estimate that changed when one trial was added Replied, post #14 · Evidence › Meta-analyses · 24 Jun 2026 · 2 likes A meta-analysis of four small trials is not stronger evidence than one adequately powered trial, whatever the summary statistic looks like.
Alcohol: what is documented and what is folklore Replied, post #58 · Practice › Interactions · 15 Jun 2026 · 18 likes Following this. I have the same question and no better information than the first post.
Micronutrient adequacy at low total intake Replied, post #100 · Nutrition & Training › Protein & intake · 14 Jun 2026 · 6 likes Self-reported intake is optimistic by a consistent margin in the published comparisons, which is worth applying to your own numbers.