Journal club: the retatrutide phase 2 obesity paper — setting out what I have, and where I think it stops being reliable.
Collecting what is known about retatrutide phase 2 obesity paper in one place, because it is currently spread across a category, two tag pages and a thread that is hard to find.
This is a summary rather than new work, and I have attributed each part to where I found it.
Bringing the previous paper on the same question makes the session much better and doubles the preparation. Worth doing every third session rather than every one.
I am describing what is, rather than arguing for what should be.
On post #4 — agreed on the reasoning, with one qualification.
Session format: read the paper before posting. The discussion is much better when everyone has. Start with the estimand and population, then methods, then results, then limitations. That order makes critique coherent.
STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most subsequent comparison. Mean weight reduction was substantially larger than anything previously achieved pharmacologically.
That is my reading. Someone else read the same page differently and was reasonable.
Read the full topic (12 posts)
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Journal club: indirect comparison between two programmes, defended and attacked
Journal club: indirect comparison between two programmes, defended and attacked Writing it up because I had to work it out twice and would rather nobody else did. Trying to work out what would count as…
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+122 | 131 | 5.2k | just now |
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Journal club: SURMOUNT-1, read without the press release
Journal club: SURMOUNT-1, read without the press release Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on SURMOUNT-1. It is mine, it is…
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+139 | 157 | 66k | 12mo |
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Journal club: SUSTAIN 6 and its retinopathy signal
On the subject in the title: Journal club: SUSTAIN 6 and its retinopathy signal Working notes rather than a conclusion. Reading SUSTAIN 6 ( N Engl J Med , 2016) for the population rather than the effect,…
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+110 | 122 | 46k | 1d |
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Journal club: SELECT, absolute risk, and how it was reported — a second dataset
On the subject in the title: Journal club: SELECT, absolute risk, and how it was reported — a second dataset Working notes rather than a conclusion. Posting a small dataset on SELECT. It is mine, it is…
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4 | 1.3k | 1mo | |
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Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset
Posting this under the heading it deserves: Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Everything below is what sits behind that. Posting a small dataset on SURMOUNT-4 and…
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+58 | 64 | 17k | 13mo |
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Run-in periods and the population they select
On the subject in the title: Run-in periods and the population they select Working notes rather than a conclusion. An honest uncertainty about run-in periods rather than a disguised assertion. I do not know…
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+130 | 142 | 7.3k | 1mo |
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Measurement error in home scales, with a worked standard deviation — a second dataset
Measurement error in home scales, with a worked standard deviation — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on Measurement error in home…
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2 | 13k | 7mo | |
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Why a glucagon receptor agonist in a weight-loss compound is not a contradiction
The question in the title: Why a glucagon receptor agonist in a weight-loss compound is not a contradiction I will give what I have already checked below so nobody repeats it. I would like to disagree…
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+43 | 47 | 19k | 2d |
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Multiplicity when you track fifteen variables
Multiplicity when you track fifteen variables — setting out what I have, and where I think it stops being reliable. Asking about multiplicity directly, because I have read four threads on it and each answered…
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2 | 60k | 11mo | |
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What a statistical analysis plan adds that the paper does not
What a statistical analysis plan adds that the paper does not — that is the question, and I have not found it answered plainly anywhere I have looked. Statistical analysis plan, and specifically the version…
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2 | 6.6k | 10h |