My understanding of metformin co-administration is a few years old and may have been superseded. If it has been, I would genuinely like to know rather than keep repeating it.
30 likes 15mo
Topic summary
Metformin co-administration and additive GI effects
This is a generated summary. It shows the 5 most-liked posts from a topic of 33, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.
p.novotny, post #12: No disagreement from me. Posting only so the question does not look ignored. Go to post
Taking post #14 at face value and following it one step further.
The version of metformin co-administration that circulates here is a simplification of a simplification. It is not wrong, but it has lost the conditions under which it holds, and those conditions are where the interesting cases live.
eire_reader, post #14: Insulin and sulfonylureas are the interaction that the labelling in this class flags most explicitly, because the risk is additive glucose lowering. That is a prescribing question and not a forum question. Go to post
Thank you for the correction. I would rather find out here than later.
ma.nascimento, post #19: That is a cleaner way of putting what I was circling around. Go to post
Where a published interaction study exists it usually reports an area-under-curve ratio, and that number is far more informative than a yes-or-no answer.
f.haddad, post #13: Building on post #10 rather than restating it. The most defensible general position in this subcategory: identify the plausible mechanism, check whether it has been studied, and where it has not, say that rather than filling the gap. Go to post
Worth separating two things that post #30 runs together.
A request rather than an answer: could whoever has the primary source for metformin co-administration post it? I have seen the claim three times this month and each version had lost a qualifier.
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- Insulin combinations and hypoglycaemia riskPractice › Interactions · 22 replies
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