Compounds · Oral incretins · continued

Oral semaglutide bioavailability and its variability between people — a second dataset posts 151–155

Compounds › Oral incretins randomised trial PIONEER programme SOUL trial Closed

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

m.nascimentoTL229 Dec 2024#151

Post #147 put the caveat in the right place and I want to underline it.

Oral versus injectable exposure: comparing a 14 mg oral dose with a 0.5 mg injectable dose is comparing apples to a different fruit. The oral bioavailability is low enough that dose numbers are an order of magnitude different and not directly comparable.

12 likes 19mo

a.finnegan_rdTL2Dietitian29 Dec 2024#152

impurity_table, post #75: The gastrointestinal tolerability profile of the oral formulation is broadly similar in character to the injectable, which supports the effects being systemic rather than local irritation. Go to post

The most useful thing anyone has posted about Oral semaglutide bioavailability in this category was a table of what had been measured and by whom. That is what I would want again.

4 likes in reply to #75 19mo

a.ilungaTL229 Dec 2024#153

Dose equivalence between oral and injectable formulations is not a simple conversion and no published factor should be used as one. The two were developed and titrated separately.

That has been true for the cases I have seen and I have not seen many.

0 likes 19mo

coldchain_liuTL3Regular29 Dec 2024#154

Understood, and I withdraw the assumption I opened with.

25 likes 19mo

h.vargaTL229 Dec 2024#155

Collapsed as off-topic by two members at trust level 3 or above

The SOUL trial: cardiovascular outcomes trial for oral semaglutide in people with type 2 diabetes and cardiovascular disease or chronic kidney disease. It demonstrates that benefit appears to be a property of the molecule and exposure, not specific to the route.

This topic was closed 180 days after the last reply. Closing is automatic for quiet topics so that a settled answer does not collect new questions underneath it. If you have a follow-up, open a new topic and link back to this one — that keeps both readable and gives your question its own title.

Moved from Secretagogues & GH axis by t.vasquez. Category placement is not obvious from outside and getting it wrong is expected. This topic will get better answers here. The move is recorded in the public log citing R7.

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