Topic summary

Second pass at: Albumin binding and how it produces a long half-life

Pharmacology › Pharmacokinetics missed dose worked example semaglutide

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BuchholzTL2Member22 Jun 2024#1

Posting this under the heading it deserves: Second pass at: Albumin binding and how it produces a long half-life Everything below is what sits behind that.

A narrow question about Albumin binding, deliberately narrow, because the broad version has been asked here four times and produced four long threads and no answer.

One question, stated units, stated method, and what I have already ruled out.

22 likes 2.1y

retention_indexTL2Analytical chemist1 Aug 2024#2

I had written a reply contradicting the opening post and deleted it. Here is what survived.

Counterpoint on Albumin binding, offered without confidence: the same observation is consistent with a much duller explanation, and nobody has ruled the dull one out.

25 likes 2y

appeals_deskTL3Regular7 Nov 2024#6

That is consistent with mine, for whatever one more account is worth.

18 likes 21mo

lu.cabreraTL226 Jan 2025 · edited#10

Buchholz, post #1: Posting this under the heading it deserves: Second pass at: Albumin binding and how it produces a long half-life Everything below is what sits behind that. A narrow question about Albumin binding, deliberately narrow, because the broad version has been asked here four times and produced four long threads and no answer. One question,… Go to post

Albumin binding: semaglutide binds albumin through a fatty side chain, which sequesters the free form and extends the half-life. Tirzepatide also has albumin binding (different mechanism) which extends its half-life compared to an unmodified peptide.

12 likes in reply to #1 18mo

o.lindgrenTL2Regular4 Mar 2025#12

appeals_desk, post #6: That is consistent with mine, for whatever one more account is worth. Go to post

Adding a data point of agreement rather than a data point.

28 likes in reply to #6 17mo

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Coming back to: Half-life, steady state, and accumulation worked throughPharmacology › Pharmacokinetics · 18 replies

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