Buchholz
TL2 Member · Pisa, IT
Here for the documentation. Occasionally files a wiki request when a page has drifted out of date.
Joined 6 May 2025 · last posted 1d
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[2026 update] Documenting an adverse event properly Replied, post #23 · Safety › Adverse events · 27 Jul 2026 · 5 likes Nothing here is medical advice, and in this subcategory the phrase is doing more work than in any other on the site.
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Seven-day rolling means and why weekly readings mislead Replied, post #113 · Outcomes › Progress reports · 26 Jul 2026 · 19 likes Coming back to post #109, because the follow-up matters more than the original answer. The documentation on seven-day rolling is better than this thread and I say that…
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CJC-1295 with and without DAC: what the modification does Replied, post #119 · Compounds › Secretagogues & GH axis · 22 Jul 2026 · 3 likes Adding the measurement that post #118 says would settle it. I would keep CJC-1295 and the decision it usually gets used for separate in this thread. They are related…
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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #80 · Practice › Dosing & titration · 20 Jul 2026 · 0 likes Stepping down deliberately: the withdrawal trials show that stopping is followed by regain. The step-down literature is thinner. The conservative assumption is that…
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I joined for one answer and stayed for a year — what changed my mind Replied, post #87 · Start Here › Welcome · 16 Jul 2026 · 1 like Welcome. The orientation materials are pinned at the top of this category and they take about an hour. They answer most of the questions a new member has and they save…
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Follow-up: The retatrutide phase 2 obesity paper, read closely Replied, post #22 · Compounds › Retatrutide · 13 Jul 2026 · 0 likes Heart rate increased in a dose-dependent way in the phase 2 work. That is not a footnote — it is one of the specific things phase 3 exists to characterise, and it is…
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Forced degradation studies: designing one that is informative Replied, post #94 · Analytics › Method validation · 9 Jul 2026 · 10 likes Picking up post #93: that is the part I would want checked first. Taking forced degradation studies seriously for a moment rather than deflecting: the honest position…
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Journal club: STEP 1 and the treatment-policy estimand Replied, post #2 · Evidence › Journal club · 8 Jul 2026 · 0 likes A methods point on STEP 1 rather than a substantive one: if the comparison is not like for like, the difference you are measuring is the difference in method.
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Why this subcategory is stricter about sourcing than most Replied, post #48 · Compounds › Secretagogues & GH axis · 26 Jun 2026 · 20 likes Following, with nothing to contribute beyond having asked the same thing elsewhere.
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Review: a draft on reconstitution arithmetic, with objections — what changed since Replied, post #30 · Documentation › Doc review · 26 Jun 2026 · 0 likes I read post #28 twice before replying, because I had assumed the opposite. Where a review raises something the author disagrees with, recording the disagreement in the…
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Search filters: what is missing Replied, post #70 · Meta › Site feedback · 17 Jun 2026 · 0 likes Useful. I had the fact and not the reason, which turns out to be the important half.
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Why the timeline is on the right and not the left — what changed since Replied, post #56 · Meta › Site feedback · 17 Jun 2026 · 2 likes Worth separating two things that post #52 runs together. Timeline: I would want to see the raw numbers rather than the summary before agreeing. Summaries lose exactly…