Vomiting: when it is expected and when it is a reason to stop — one year on

Vomiting: when it is expected and when it is a reason to stop — one year on Writing it up because I had to work it out twice and would rather nobody else did.

Reporting something rather than asking about it, in case the pattern is useful to anyone else.

Over 16 weeks I logged this consistently: date, dose, time of day, and a simple severity score from 0 to 4 for each symptom. That is 178 data points, all self-reported, all unblinded, and collected by someone who knew what he expected to find. Treat it accordingly.

The reason I am posting is that my experience does not match the shape people usually describe here, and I would like to know whether that is unusual or whether the usual description is just the loudest version.

The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation.

I would rather post the uncertainty than round it away.

The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by who chooses to post.

Severe, persistent abdominal pain, especially radiating to the back, is in a different category from ordinary gastrointestinal upset and is a reason to seek medical assessment rather than to post about it.

Tracking severity on a simple scale with dates is far more useful than describing it afterwards. Memory smooths a symptom curve into a story that fits what you expected.

Posting it because the silence on this was starting to look like agreement.