Vomiting: when it is expected and when it is a reason to stop — one year on

Vomiting: when it is expected and when it is a reason to stop — one year on Writing it up because I had to work it out twice and would rather nobody else did.

Reporting something rather than asking about it, in case the pattern is useful to anyone else.

Over 16 weeks I logged this consistently: date, dose, time of day, and a simple severity score from 0 to 4 for each symptom. That is 178 data points, all self-reported, all unblinded, and collected by someone who knew what he expected to find. Treat it accordingly.

The reason I am posting is that my experience does not match the shape people usually describe here, and I would like to know whether that is unusual or whether the usual description is just the loudest version.

Confirming the opening post from a second method, which matters more than confirming it from a second person.

The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation.

If anyone has run this properly I would rather read that than my own guess.

The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by who chooses to post.

The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation.

Coming back to the opening post, because the follow-up matters more than the original answer.

The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by who chooses to post.

If anyone can point at the primary source I would be grateful.

The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation.

I would rather post the uncertainty than round it away.

The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by who chooses to post.

I would call that likely rather than established.

Nothing to add on the substance. Thank you for taking the question at face value.

The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation.

The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by who chooses to post.

Picking up post #10: that is the part I would want checked first.

The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation.

On post #9 — agreed on the reasoning, with one qualification.

The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by who chooses to post.

Not disagreeing with anyone above, just adding the bit I keep having to look up.

The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation.

It is a small point and it changes the answer, which is an awkward combination.

Severe, persistent abdominal pain, especially radiating to the back, is in a different category from ordinary gastrointestinal upset and is a reason to seek medical assessment rather than to post about it.