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Topic summary

What SELECT changed about how semaglutide is discussed, and what it did not

This is a generated summary. It shows the 9 most-liked posts from a topic of 133, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.
PF
p.friskTL229 Jan 2025#1

Asking directly, because I could not find a straight answer: What SELECT changed about how semaglutide is discussed, and what it did not

I was wrong about SELECT in a thread last spring and I would like to correct it publicly rather than quietly.

The error was in the units, which changed the conclusion by an order of magnitude. Setting out the corrected version, and the way I now check for that class of mistake.

37 likes 18mo
AE
a.eriksenTL2 Solution7 Feb 2025#6

The most useful reply I ever got about SELECT was a request to state my units. It sounds like pedantry and it has saved me twice.

28 likes 18mo
NT
n.torrenceTL3Regular26 Feb 2025#22

What I would want before treating SELECT as settled: the method, the sample, and whether anyone tried to find the opposite result. Two of the three are usually missing.

30 likes 17mo
GR
g.rasmussenTL29 Mar 2025#34
p.boateng, post #12: Discontinuation rates in the trials are worth reading alongside efficacy and almost never are. A large mean effect in a population where a meaningful fraction stopped early is telling you two things, not one. One of those cases where knowing the mechanism does not help the decision. Go to post

What I would check first on SELECT is whether the thing being measured moved or whether the way of measuring it moved. Those look identical in a graph.

28 likes in reply to #12 17mo
SG
s.girardTL23 Apr 2025#63

Acknowledging rather than arguing. The reasoning holds as far as I can follow it.

33 likes 16mo
SK
s.karlsen_rphTL3Pharmacist9 Apr 2025 · edited#70

Answering the question post #66 raises rather than the one it answers.

SELECT: I have looked for the primary source twice and failed twice. Either it does not exist or it is somewhere I do not know to look, and I would like to know which.

32 likes 16mo
RT
r.torrenceTL2Member11 Apr 2025#73
crossref_check, post #66: The C-cell question: semaglutide triggered medullary thyroid carcinoma in rodent toxicology studies. A signal in rodents does not automatically appear in humans, but it is the reason the compound is contraindicated in people with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2. Worth… Go to post

SELECT has a well-known answer and a correct answer, and the interesting work is establishing that they are the same. Nobody has done that here yet.

31 likes in reply to #66 16mo
GD
g.danquahTL218 Apr 2025#82

The opalescent appearance in semaglutide solutions is occasionally noted and the mechanism is unclear. It does not appear to correlate with product failure in practice. Visible particles or frank cloudiness is different and would be reason to contact the supplier.

29 likes 15mo
AN
a.norgaardTL213 May 2025#116

Before the thread moves on from SELECT — what is the sample size behind the claim? I am not being difficult; I have seen the same figure quoted from an n of four and from an n of four hundred.

30 likes 15mo

Read the full topic (133 posts)

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