Research-use-only oral material is not a licensed tablet and there is no reason to assume it carries a functioning absorption-enhancement system at all. The formulation is most of the product here.
Asking directly, because I could not find a straight answer: Why oral semaglutide needs an absorption enhancer at all — what changed since
What changes if the standard account of oral semaglutide is wrong? I ask because I have been treating it as settled and I noticed this week that I could not say why.
Working through the consequences rather than the evidence, since others here are better placed on the evidence.
Adding the measurement that post #2 says would settle it.
Anyone comparing published oral and injectable efficacy should check whether the comparison is within one trial or across two. Across two, the populations differ and the comparison is weak.
Happy to be the one who is wrong here if it settles the question.
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Orforglipron as a non-peptide: what changes when the molecule is small
On the subject in the title: Orforglipron as a non-peptide: what changes when the molecule is small Working notes rather than a conclusion. What changes if the standard account of orforglipron is wrong? I ask…
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+26 | 30 | 26k | 23mo |
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Oral versus injectable exposure: comparing apples to a different fruit — a second dataset
Posting this under the heading it deserves: Oral versus injectable exposure: comparing apples to a different fruit — a second dataset Everything below is what sits behind that. Something about Oral versus…
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+27 | 31 | 17k | 25d |
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Coming back to: The SOUL trial and oral semaglutide cardiovascular outcomes
The SOUL trial and oral semaglutide cardiovascular outcomes — setting out what I have, and where I think it stops being reliable. SOUL trial and oral semaglutide — I have the observation and I do not trust my…
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+100 | 104 | 4.2k | 5mo |
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Why fasting instructions for oral semaglutide are not optional advice
Why fasting instructions for oral semaglutide are not optional advice I have a specific reason for asking rather than idle curiosity, and the context is below. Fasting instructions for oral semaglutide, from…
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+70 | 74 | 1.1k | 23d |
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Revisiting: Food effects on oral incretin absorption: what is documented
Revisiting: Food effects on oral incretin absorption: what is documented — setting out what I have, and where I think it stops being reliable. Food effects on oral incretin, from the point of view of someone…
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+6 | 10 | 51k | 13mo |
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Oral semaglutide bioavailability and its variability between people
Posting this under the heading it deserves: Oral semaglutide bioavailability and its variability between people Everything below is what sits behind that. I would like to know what people here actually do…
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+44 | 48 | 574 | 3mo |
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Why tirzepatide titration schedules have more steps than semaglutide's
Asking directly, because I could not find a straight answer: Why tirzepatide titration schedules have more steps than semaglutide's I have spent a fortnight trying to pin tirzepatide titration schedules down…
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4 | 8.4k | 7mo | |
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Revisiting: Food effects on oral incretin absorption: what is documented
Revisiting: Food effects on oral incretin absorption: what is documented — setting out what I have, and where I think it stops being reliable. Food effects on oral incretin, from the point of view of someone…
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+6 | 10 | 51k | 13mo |
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Oral versus injectable exposure: comparing apples to a different fruit
Oral versus injectable exposure: comparing apples to a different fruit — setting out what I have, and where I think it stops being reliable. Something about oral versus injectable exposure does not reconcile…
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+19 | 23 | 332 | 8mo |
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Journal club: FLOW and the renal composite, component by component
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+84 | 91 | 18k | 2y |