IRenaudin
TL2 Member · Lausanne, CH
UK-based. Mostly the access and pricing categories.
Joined 5 February 2025 · last posted 2d · groups: regional-uk
85Posts here
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GLP-1 receptor distribution: central and peripheral Replied, post #98 · Pharmacology › Receptor biology · 26 Jul 2026 · 1 like Species differences in receptor pharmacology are substantial in this family, which is one reason rodent data has translated unevenly.
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An 18-month record including the parts that went badly Replied, post #78 · Outcomes › Progress reports · 23 Jul 2026 · 0 likes Where I part company with post #75, and it is a narrow parting. Photographs at fixed intervals under fixed conditions are a better record of composition change than the…
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PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one Replied, post #20 · Compounds › Oral incretins · 23 Jul 2026 · 1 like I had written a reply contradicting post #19 and deleted it. Here is what survived. Timing consistency matters more for oral dosing than for weekly injection, because…
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Specificity, linearity, accuracy, precision, range, robustness — with real criteria Replied, post #46 · Analytics › Method validation · 20 Jul 2026 · 6 likes Building on post #43 rather than restating it. Specificity: the method can distinguish the intended compound from related impurities and degradation products. Tested by…
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Private prescribing in the UK: what is actually involved Replied, post #65 · Regional › UK & Ireland · 15 Jul 2026 · 2 likes Occupational health screening: some UK occupations require medical checks. Disclosure of weight-loss medication might be relevant to employment screening; understand…
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Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Replied, post #2 · Compounds › Retatrutide · 11 Jul 2026 · 29 likes Fine by me. I had wanted a stronger conclusion and there is not one available.
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Follow-up: Reading an interaction checker output critically Replied, post #35 · Practice › Interactions · 7 Jul 2026 · 1 like Where a published interaction study exists it usually reports an area-under-curve ratio, and that number is far more informative than a yes-or-no answer.
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How much context is too much context in a first post? Replied, post #20 · Start Here › How to Ask · 6 Jul 2026 · 13 likes Understood. Thank you for being specific about the limits of it.
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NHS criteria and how they are applied in practice Replied, post #15 · Regional › UK & Ireland · 30 Jun 2026 · 24 likes Cross-border arrangements: some people source from other EU countries. Rules on import for personal use are changing post-Brexit. Current status requires checking with…
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Journal club: indirect comparison between two programmes, defended and attacked Replied, post #100 · Evidence › Journal club · 28 Jun 2026 · 0 likes I had written a reply contradicting post #96 and deleted it. Here is what survived. STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the…
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[2026 update] A vial that will not fully dissolve: what to check and in what order Replied, post #110 · Practice › Reconstitution · 15 Jun 2026 · 5 likes Appreciated. The plain phrasing does more work here than a longer post would.
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What consumer-accessible tests can and cannot determine — a second dataset Started this topic · Analytics › Home & field testing · 12 Jun 2026 · 17 likes What consumer-accessible tests can and cannot determine — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below.…