IRenaudin

TL2 Member · Lausanne, CH

UK-based. Mostly the access and pricing categories.

Joined 5 February 2025 · last posted 2d · groups: regional-uk

85 posts, newest first. Showing up to 150.

GLP-1 receptor distribution: central and peripheral Replied, post #98 · Pharmacology › Receptor biology · 26 Jul 2026 · 1 like Species differences in receptor pharmacology are substantial in this family, which is one reason rodent data has translated unevenly.
An 18-month record including the parts that went badly Replied, post #78 · Outcomes › Progress reports · 23 Jul 2026 · 0 likes Where I part company with post #75, and it is a narrow parting. Photographs at fixed intervals under fixed conditions are a better record of composition change than the…
PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one Replied, post #20 · Compounds › Oral incretins · 23 Jul 2026 · 1 like I had written a reply contradicting post #19 and deleted it. Here is what survived. Timing consistency matters more for oral dosing than for weekly injection, because…
Specificity, linearity, accuracy, precision, range, robustness — with real criteria Replied, post #46 · Analytics › Method validation · 20 Jul 2026 · 6 likes Building on post #43 rather than restating it. Specificity: the method can distinguish the intended compound from related impurities and degradation products. Tested by…
Private prescribing in the UK: what is actually involved Replied, post #65 · Regional › UK & Ireland · 15 Jul 2026 · 2 likes Occupational health screening: some UK occupations require medical checks. Disclosure of weight-loss medication might be relevant to employment screening; understand…
Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Replied, post #2 · Compounds › Retatrutide · 11 Jul 2026 · 29 likes Fine by me. I had wanted a stronger conclusion and there is not one available.
Follow-up: Reading an interaction checker output critically Replied, post #35 · Practice › Interactions · 7 Jul 2026 · 1 like Where a published interaction study exists it usually reports an area-under-curve ratio, and that number is far more informative than a yes-or-no answer.
How much context is too much context in a first post? Replied, post #20 · Start Here › How to Ask · 6 Jul 2026 · 13 likes Understood. Thank you for being specific about the limits of it.
NHS criteria and how they are applied in practice Replied, post #15 · Regional › UK & Ireland · 30 Jun 2026 · 24 likes Cross-border arrangements: some people source from other EU countries. Rules on import for personal use are changing post-Brexit. Current status requires checking with…
Journal club: indirect comparison between two programmes, defended and attacked Replied, post #100 · Evidence › Journal club · 28 Jun 2026 · 0 likes I had written a reply contradicting post #96 and deleted it. Here is what survived. STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the…
[2026 update] A vial that will not fully dissolve: what to check and in what order Replied, post #110 · Practice › Reconstitution · 15 Jun 2026 · 5 likes Appreciated. The plain phrasing does more work here than a longer post would.
What consumer-accessible tests can and cannot determine — a second dataset Started this topic · Analytics › Home & field testing · 12 Jun 2026 · 17 likes What consumer-accessible tests can and cannot determine — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below.…
Micronutrient adequacy at low total intake Replied, post #65 · Nutrition & Training › Protein & intake · 11 Jun 2026 · 0 likes Where intake has fallen a long way, protein is usually the first thing to fall because it is the least appealing macronutrient when appetite is reduced.
Request: a per-category review queue Replied, post #29 · Meta › Feature requests · 10 Jun 2026 · 1 like Post #25 put the caveat in the right place and I want to underline it. Alternatives: if you have thought of a way the current site might already serve your need,…
Prescription portability between countries Replied, post #54 · Access › International · 5 Jun 2026 · 8 likes No disagreement from me. Posting only so the question does not look ignored.
[2026 update] Area percent versus weight percent: the confusion that causes most arguments Replied, post #50 · Analytics › HPLC & UHPLC · 29 May 2026 · 2 likes System suitability testing: injections run before and during the sample run to establish whether the instrument, column and method were performing when the sample was…
Clearance pathways and what renal impairment changes Replied, post #16 · Pharmacology › Pharmacokinetics · 26 May 2026 · 5 likes A pharmacokinetic model fitted to trial data describes the population studied. Applying it to somebody outside the enrolled range is an extrapolation, and the model…
What to include when your question involves a chromatogram — one year on Replied, post #8 · Start Here › How to Ask · 17 May 2026 · 15 likes Post #4 put the caveat in the right place and I want to underline it. Disagreeing with an answer you got: cite what you disagree with, say what contradicts it, and ask…
Forced degradation studies: designing one that is informative Replied, post #56 · Analytics › Method validation · 15 May 2026 · 29 likes The limit of quantitation determines what the impurity table can honestly contain. Peaks below it can be reported as detected and cannot be reported as a number. Take…
Reading a trial's population section before its results Replied, post #22 · Evidence › Trials · 15 May 2026 · 25 likes Population narrowness: most trials in this class enrolled fairly specific groups. Baseline body mass index ranges, exclusion of renal disease, exclusion of certain…
Subgroup analyses: pre-specified versus discovered — a second dataset Replied, post #73 · Evidence › Trials · 5 May 2026 · 22 likes Nothing to add, except that this is the answer I would give if asked.
Foaming during reconstitution and whether it matters — the long version Replied, post #113 · Practice › Reconstitution · 26 Apr 2026 · 16 likes Offering a way to settle Foaming during reconstitution rather than another opinion about it. Two measurements, taken the same way, a fortnight apart. If the difference…
Journal club: orforglipron phase 2 and the non-peptide question Replied, post #46 · Evidence › Journal club · 24 Apr 2026 · 2 likes Post #43 is the version of this I will quote in future. One addition. The most useful reply I ever got about orforglipron phase 2 was a request to state my units. It…
List price versus negotiated price versus what you pay Replied, post #94 · Access › Pricing · 16 Apr 2026 · 6 likes Post #91 is right about the mechanism and I think understates the practical bit. A definition problem is doing most of the work in this list price versus negotiated…
List price versus negotiated price versus what you pay Replied, post #71 · Access › Pricing · 14 Apr 2026 · 7 likes Nobody has said the unglamorous part of list price versus negotiated price yet, so: most of the variation is explained by things that are boring to write about and easy…
Second pass at: Which categories are strict and which are relaxed, honestly Replied, post #32 · Start Here › Welcome · 29 Mar 2026 · 0 likes Trust levels accumulate over time and they give you access to small things like the ability to edit your own posts without a timestamp. They are not a status symbol and…
Price changes over 2025 and 2026, tabulated and dated — does this still hold? Replied, post #118 · Access › Pricing · 17 Mar 2026 · 2 likes Where somebody posts a comparison, the useful version states the date, the region and what was included.
Nausea profile of amylin analogues compared with GLP-1 agonists Replied, post #27 · Compounds › Cagrilintide & amylin analogues · 25 Feb 2026 · 2 likes I read the earlier replies on nausea profile of amylin analogues twice before writing this, because I had assumed the opposite and wanted to be sure I was disagreeing…
Second pass at: Temperature logging at home: what is worth the effort Replied, post #3 · Practice › Storage & stability · 17 Feb 2026 · 0 likes Building on the opening post rather than restating it. Published stability data applies specifically to the formulation studied, under the specific conditions stated.…
Pinch or no pinch, and how needle length changes the answer — the long version Replied, post #17 · Practice › Administration · 7 Feb 2026 · 0 likes Injecting into an area that has become firm: lipohypertrophy — thickened fatty tissue from repeated injection in one area — changes local tissue absorption. Avoid…
Storing lyophilised material long term: what governs the shelf life Replied, post #48 · Practice › Storage & stability · 2 Feb 2026 · 0 likes Storing lyophilised material long term is a question about a distribution, not about a value, and treating it as a value is what produces the confident wrong answers.
Pen mechanics when the cartridge is nearly empty — does this still hold? Replied, post #46 · Devices › Pens & autoinjectors · 19 Jan 2026 · 7 likes I read post #44 twice before replying, because I had assumed the opposite. A pen taken straight from the refrigerator is uncomfortable to inject for the same reason a…
Adducts: sodium, potassium, and the peak you did not expect — does this still hold? Replied, post #10 · Analytics › Mass spectrometry · 16 Jan 2026 · 14 likes Post #8 put the caveat in the right place and I want to underline it. Two claims get bundled together under Adducts and they need separating. The descriptive one — this…
Aggregates and why a purity assay may miss them entirely Replied, post #56 · Analytics › Impurities & related substances · 7 Jan 2026 · 18 likes Everything in post #53 holds. The case it does not cover is the one I have. Reporting thresholds matter: below a stated threshold, peaks are usually not reported at…
A partial dose because the pen emptied mid-injection Started this topic · Practice › Administration · 6 Jan 2026 · 13 likes A partial dose because the pen emptied mid-injection Writing it up because I had to work it out twice and would rather nobody else did. A methods question rather than a…
Request: a diff view for wiki revisions — the long version Replied, post #90 · Meta › Feature requests · 27 Dec 2025 · 9 likes Effort estimation: some features are trivial to implement; others are substantial work. Staff will estimate effort when assessing whether a feature is feasible. If the…
Personal import allowances, compared Replied, post #6 · Access › International · 20 Dec 2025 · 1 like Import rules for personal quantities are jurisdiction-specific and change without much publicity. Establishing your own position is unavoidable. One case, stated as one…
The decimal-point error, and the habit that catches it Replied, post #96 · Practice › Reconstitution · 17 Dec 2025 · 9 likes Worth separating two things that post #92 runs together. I would rather this thread reach "we do not know" about decimal-point error than reach a confident answer that…
Second pass at: What "verified" means on our vendor pages, stated narrowly Replied, post #45 · Sourcing › Vendor reports · 13 Dec 2025 · 6 likes Where I part company with post #41, and it is a narrow parting. Dosing and purity: a vial that is 99% pure might contain 80% of its label claim if the other mass is…
Introducing myself: pharmacist, sceptic, reluctant participant Started this topic · Lounge › Introductions · 10 Dec 2025 · 30 likes Introducing myself: pharmacist, sceptic, reluctant participant Writing it up because I had to work it out twice and would rather nobody else did. Introducing myself…
[2026 update] Are there stupid questions here? A staff answer, at length Replied, post #9 · Start Here › Welcome · 21 Nov 2025 · 11 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
High-resolution MS on aggregates and what it can see Replied, post #121 · Analytics › Mass spectrometry · 15 Nov 2025 · 4 likes The documentation on high-resolution is better than this thread and I say that as someone who has posted in the thread.
Anxiety in the first weeks: drug, situation, or both — what changed since Replied, post #48 · Wellbeing › Mental health · 10 Nov 2025 · 29 likes The social side of this — how other people respond to visible change — comes up constantly and has nothing to do with pharmacology.
New subcategory: rationale and scope Replied, post #133 · Meta › Announcements · 27 Oct 2025 · 1 like Thank you for announcing it in advance rather than after. The number of places that do the reverse is remarkable. Stating my assumptions rather than smuggling them in.
Second pass at: Robustness: the parameters worth deliberately varying Replied, post #21 · Analytics › Method validation · 24 Oct 2025 · 25 likes That is clearer than the version I had in my head. Thank you.
What happens after your first post: likes, trust levels, and why none of it matters much… Replied, post #109 · Start Here › Welcome · 22 Oct 2025 · 3 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
Payment mechanics and the recovery options that do not exist Replied, post #65 · Sourcing › Payments · 21 Oct 2025 · 15 likes Summarising the payment mechanics thread so far, since it is long and the answer is buried: the first reply has the method, the fourth has the correction to it, and the…
The headache that turns out to be dehydration Replied, post #29 · Nutrition & Training › Hydration & electrolytes · 20 Oct 2025 · 5 likes The claim about headache upthread is stronger than its source supports. I have read the source. The source says "associated with" and the post says "causes".
Citing a preprint in a maintained document: our rule and its reasoning — does this still… Replied, post #96 · Evidence › Preprints · 3 Oct 2025 · 4 likes Coming back to post #94, because the follow-up matters more than the original answer. Speaking only to Citing a preprint as I have actually seen it, rather than as it…
Dose numbers across compounds are not on the same scale Replied, post #2 · Practice › Dosing & titration · 14 Sep 2025 · 32 likes A missed dose in a weekly schedule is not a trough to chase. With a week-long half-life you are perturbing a slowly moving average, and the labelling for licensed…
Titles that describe the question, not the situation — what changed since Replied, post #11 · Start Here › How to Ask · 12 Sep 2025 · 0 likes Post #9 and I disagree about the size of the effect, not about the direction. Second-hand on Titles, so weight it accordingly — someone whose method I trust told me…
Persistent vomiting and the threshold for seeking help Replied, post #31 · Safety › Adverse events · 9 Sep 2025 · 30 likes I read post #30 twice before replying, because I had assumed the opposite. The version of persistent vomiting that circulates here is a simplification of a…
A calculator that gives a right answer to the wrong question — does this still hold? Replied, post #10 · Data & Tools › Calculators · 7 Sep 2025 · 16 likes Post #9 answers the question as asked. The question underneath it is different. Nothing a calculator produces is medical advice, and a correct calculation on…
Sample size calculations, read backwards from the published number Started this topic · Evidence › Trials · 4 Sep 2025 · 2 likes Sample size calculations, read backwards from the published number Writing it up because I had to work it out twice and would rather nobody else did. Asking about…
Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one — one… Replied, post #2 · Compounds › Oral incretins · 1 Sep 2025 · 30 likes PIONEER 6 is the cardiovascular outcome trial for oral semaglutide and it enrolled a diabetes population at high cardiovascular risk. Quoting it outside that population…
Tracking that stops updating and then resumes Replied, post #21 · Sourcing › Logistics · 26 Aug 2025 · 0 likes Useful. I had the fact and not the reason, which turns out to be the important half.
How to research a compound with no human data without deceiving yourself Replied, post #22 · Compounds › Other compounds · 31 Jul 2025 · 3 likes Naming conventions for research peptides cause confusion because suppliers do not follow a standard. The same compound gets different names from different suppliers. If…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Replied, post #162 · Practice › Reconstitution · 12 Jul 2025 · 4 likes If your arithmetic gives a volume smaller than one graduation on your syringe, the answer is a lower concentration rather than a more careful hand. Take the reasoning…
Lipase elevation without symptoms: the interpretation problem Started this topic · Clinical › Bloodwork · 1 Jun 2025 · 44 likes Lipase elevation without symptoms: the interpretation problem Writing it up because I had to work it out twice and would rather nobody else did. Lipase elevation…
Second pass at: Retatrutide mass and identity: what a report should show Replied, post #55 · Compounds › Retatrutide · 29 May 2025 · 5 likes Mass and identity: a report on retatrutide should state the mass detected by LC-MS, not assume a theoretical mass. The theoretical mass is not published in…
Pre-registering a personal experiment, seriously Replied, post #41 · Research Methods › N-of-1 designs · 29 May 2025 · 15 likes On post #37 — agreed on the reasoning, with one qualification. Record everything that changed, not just the intervention. Personal experiments are confounded by life,…
Coming back to: Getting a referral rather than a refusal Replied, post #7 · Clinical › Prescriber conversations · 27 May 2025 · 17 likes Asking what would change the plan is more productive than asking whether the plan is right. It gets you the decision criteria rather than a verdict.
Forced degradation studies: designing one that is informative — does this still hold? Replied, post #4 · Analytics › Method validation · 27 May 2025 · 0 likes Transfer between laboratories: a method can be transferred from one lab to another, but the receiving lab needs to demonstrate that they can achieve the same…
Second pass at: Reading a combination trial: attributing effect to components Replied, post #16 · Compounds › Cagrilintide & amylin analogues · 15 May 2025 · 18 likes The monoisotopic mass sits near 3749.9 Da, and the same caveat applies as everywhere else: a mass consistent with the proposed structure is a necessary condition and…
Adjudicated events and why the definition matters — the long version Replied, post #137 · Evidence › Trials · 5 May 2025 · 13 likes My position on Adjudicated events is current rather than settled. I have revised it once already and I expect to again, so treat it accordingly.
Distinguishing a deletion sequence by mass alone — the long version Replied, post #17 · Analytics › Mass spectrometry · 28 Apr 2025 · 3 likes On post #15 — agreed on the reasoning, with one qualification. Response in electrospray is not proportional to abundance across different species. Using peak…
Review: a draft on reconstitution arithmetic, with objections Replied, post #115 · Documentation › Doc review · 20 Apr 2025 · 0 likes Coming back to post #113, because the follow-up matters more than the original answer. Nothing in a maintained document is medical advice and the review should confirm…
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #53 · Evidence › Journal club · 19 Apr 2025 · 0 likes On STEP 1, the part that usually goes wrong is that the question is asked as though it has one answer. It has a range, and the width of the range is the interesting…
A report I filed that turned out to be wrong, and the correction Replied, post #19 · Sourcing › Vendor reports · 19 Apr 2025 · 3 likes The cost of a submission is worth stating. It is the main reason people do not do this and knowing the figure helps somebody else decide. Worth one more sentence than…
An emergency department visit, described afterwards Replied, post #12 · Safety › Adverse events · 17 Apr 2025 · 0 likes No disagreement from me. Posting only so the question does not look ignored.
Why fasting instructions for oral semaglutide are not optional advice — does this still… Replied, post #16 · Compounds › Oral incretins · 10 Apr 2025 · 7 likes Oral semaglutide's bioavailability is low and variable, which is why the dose numbers are an order of magnitude different from the injectable. That is a formulation…
Telehealth prescribing models in the US Replied, post #73 · Regional › North America · 20 Mar 2025 · 31 likes Formulary position changes on a schedule that is published in advance, which means a decision made now may be answering last year's formulary. I have no interest in any…
Coming back to: Sample size calculations, read backwards from the published number Replied, post #2 · Evidence › Trials · 13 Mar 2025 · 19 likes The reason Sample size calculations keeps being re-asked is that the answer is conditional and people quote it without the condition. It is not that the answer is…
Why fasting instructions for oral semaglutide are not optional advice — does this still… Replied, post #5 · Compounds › Oral incretins · 11 Mar 2025 · 12 likes Fasting instructions are not optional advice. Taking the tablet with food or with more than a sip of water measurably reduces absorption. This is the one compound in…
Validating a method you did not develop — does this still hold? Replied, post #85 · Analytics › Method validation · 7 Mar 2025 · 27 likes An independent laboratory's method being different from the supplier's is not a discrepancy. It becomes one only when the results differ by more than both methods'…
Revisiting: German, French and Dutch differences, compared Started this topic · Regional › European Union · 1 Mar 2025 · 0 likes Posting this under the heading it deserves: Revisiting: German, French and Dutch differences, compared Everything below is what sits behind that. I have spent a…
Counter-ion form: the field almost nobody reports — one year on Replied, post #25 · Analytics › COA interpretation · 25 Feb 2025 · 0 likes Purity and content are different measurements: purity tells you what proportion of the detected material is the intended species. Content tells you how much of the…
Deamidation and the close-eluting pair it produces Started this topic · Analytics › Impurities & related substances · 20 Feb 2025 · 27 likes Deamidation and the close-eluting pair it produces Writing it up because I had to work it out twice and would rather nobody else did. Something about deamidation does…
Random versus fixed effects: choosing rather than defaulting — a second dataset Replied, post #79 · Evidence › Meta-analyses · 9 Feb 2025 · 31 likes Fixed-effects versus random-effects models: fixed-effects assumes all studies are estimating the same thing and variation is sampling error. Random-effects assumes…
Fixed versus detachable needles: the trade-offs Replied, post #113 · Devices › Syringes & needles · 15 Jan 2025 · 6 likes Taking post #112 at face value and following it one step further. Two claims get bundled together under fixed versus detachable needles and they need separating. The…
What we do not know about retatrutide, listed explicitly Replied, post #40 · Compounds › Retatrutide · 1 Jan 2025 · 27 likes I had written a reply contradicting post #36 and deleted it. Here is what survived. Heart rate increased in a dose-dependent way in the phase 2 work. That is not a…
Second pass at: How to research a compound with no human data without deceiving yourself Replied, post #3 · Compounds › Other compounds · 6 Dec 2024 · 0 likes Research use only, not approved for human use, and in this subcategory the compounds vary enormously in how much is known about them. It is worth establishing which end…
Type 1 diabetes: off-label use and the evidence gap — what changed since Replied, post #73 · Clinical › Special populations · 25 Nov 2024 · 22 likes Acknowledging rather than arguing. The reasoning holds as far as I can follow it.
Transit times by route, from a logged dataset — the long version Replied, post #27 · Sourcing › Logistics · 7 Nov 2024 · 3 likes Confirming post #26 from a second method, which matters more than confirming it from a second person. Import restrictions by jurisdiction: what is legal to import for…
Reporting a discrepancy without making an allegation Replied, post #21 · Sourcing › Vendor reports · 10 Aug 2024 · 1 like This follows post #20 rather than contradicting it. The reason reporting a discrepancy keeps being re-asked is that the answer is conditional and people quote it…