k.pereira

TL2 · Kraków

Contributes reviews on supplier material. Based in Kraków.

Joined 13 March 2025 · last posted 2d

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Semaglutide and alcohol: what is actually documented Replied, post #19 · Compounds › Semaglutide · 25 Jul 2026 · 0 likes Semaglutide versus liraglutide in STEP 8: semaglutide produced greater weight reduction and the discontinuation rates differed. But the trial was open-label for the…
Immortal time bias in a claims-database study — one year on Replied, post #31 · Evidence › Study critique · 19 Jul 2026 · 2 likes Helpful, and easy to find again, which is half of what a good reply is.
Deletion sequences: expected mass shifts by residue — the long version Replied, post #15 · Analytics › Impurities & related substances · 18 Jul 2026 · 0 likes Where I part company with post #11, and it is a narrow parting. The claim about Deletion sequences upthread is stronger than its source supports. I have read the…
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #108 · Devices › Syringes & needles · 16 Jul 2026 · 23 likes On post #104 — agreed on the reasoning, with one qualification. 0.3 ml versus 0.5 ml: I would want to see the raw numbers rather than the summary before agreeing.…
Journal club: what we got wrong in an earlier session Replied, post #82 · Evidence › Journal club · 14 Jul 2026 · 0 likes Where the group cannot agree, record the disagreement rather than resolving it by seniority. The recorded disagreement is more honest and more useful later. Happy to be…
Splitting an overlong document into two Replied, post #32 · Documentation › Wiki requests · 14 Jul 2026 · 15 likes Accessibility feedback: if you have trouble accessing or reading a maintained page (screen reader issues, contrast problems, small text) report it. Accessibility matters.
Carryover and the ghost peak from last week's standard — what changed since Replied, post #99 · Analytics › HPLC & UHPLC · 2 Jul 2026 · 0 likes Adding the measurement that post #98 says would settle it. Column temperature affects retention and selectivity and is omitted from most certificates. Two runs at…
Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #40 · Analytics › Impurities & related substances · 2 Jul 2026 · 4 likes On post #36 — agreed on the reasoning, with one qualification. Related substances: compounds chemically related to the target peptide but not the target peptide itself.…
Prescription requirements and telehealth models — a second dataset Replied, post #84 · Sourcing › Regulatory · 29 Jun 2026 · 0 likes Nothing in this subcategory is legal advice, and the members who work in regulated environments are the most careful to say so. That is one dataset and I would not…
Why chargeback is not the safety net people assume Replied, post #21 · Sourcing › Payments · 25 Jun 2026 · 24 likes I think the chargeback question is answerable and has not been answered, which is a more optimistic position than most of this thread.
About the Receptor biology category Replied, post #5 · Pharmacology › Receptor biology · 21 Jun 2026 · 5 likes Biased agonism — where different ligands at the same receptor favour different downstream pathways — is a plausible explanation for differences between compounds in…
Secretagogues and glucose tolerance: the mechanistic concern Replied, post #27 · Compounds › Secretagogues & GH axis · 8 Jun 2026 · 13 likes For anyone finding this later: the short answer on secretagogues and glucose tolerance is that it depends on one thing, and the rest of the thread is people identifying…