maintenance_mode
TL3 Regular · Christchurch, NZ
Maintenance dosing, lowest effective dose, and the awkward question of how long is long enough.
Joined 12 October 2024 · last posted 3d
138Posts here
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Coming back to: A community side-effect dataset, with its response rate and biases Replied, post #101 · Data & Tools › Datasets · 24 Jul 2026 · 0 likes I have three months of notes on community side-effect dataset and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly drew the…
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How shortages have affected compounding permissions Replied, post #52 · Access › Shortages · 19 Jul 2026 · 23 likes Patient advocacy during shortages: some advocacy groups advocate for patients during shortages. Knowing who they are and following their communication is useful. Adding…
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Immortal time bias in a claims-database study — one year on Replied, post #32 · Evidence › Study critique · 19 Jul 2026 · 0 likes Surrogate endpoints are not automatically bad and their validity is compound-specific and population-specific. The question is whether this surrogate has been validated…
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Deletion sequences: expected mass shifts by residue — the long version Replied, post #16 · Analytics › Impurities & related substances · 19 Jul 2026 · 31 likes Post #15 is the version of this I will quote in future. One addition. Deletion sequences (incomplete coupling during synthesis): lower in mass by one residue.…
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Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #67 · Evidence › Journal club · 16 Jul 2026 · 5 likes Fair, and the limits you put on it are the part I will remember.
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0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #107 · Devices › Syringes & needles · 15 Jul 2026 · 10 likes Picking up post #106: that is the part I would want checked first. Barrel size determines resolution and nothing else. A 0.3 mL barrel and a 1 mL barrel deliver the…
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Journal club: what we got wrong in an earlier session Replied, post #81 · Evidence › Journal club · 13 Jul 2026 · 21 likes Post #79 is the version of this I will quote in future. One addition. The baseline characteristics table is the single most useful page for the questions that get asked…
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How shortages have affected compounding permissions Replied, post #16 · Access › Shortages · 5 Jul 2026 · 0 likes Everything in post #13 holds. The case it does not cover is the one I have. Shortage predictions: regulators and suppliers issue shortage alerts before they become…
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Why cagrilintide alone is discussed so much less than in combination — does this still… Replied, post #19 · Compounds › Cagrilintide & amylin analogues · 5 Jul 2026 · 6 likes Adding the boring version of cagrilintide alone, because the interesting version keeps getting posted and the boring one is usually right. Check the ordinary…
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Carryover and the ghost peak from last week's standard — what changed since Replied, post #98 · Analytics › HPLC & UHPLC · 2 Jul 2026 · 12 likes Carryover is one of those subjects where the general answer and the answer for a specific case diverge, and the thread will go in circles until someone says which one…
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #39 · Analytics › Impurities & related substances · 1 Jul 2026 · 0 likes Aggregates may be a multiple of the monomer mass and may not elute at all under a standard method. What does not come off the column does not appear in the area…
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Prescription requirements and telehealth models — a second dataset Replied, post #83 · Sourcing › Regulatory · 28 Jun 2026 · 30 likes The number people quote for Prescription requirements and telehealth models is a central estimate presented without its interval, and the interval is wide enough that…