pe.onwuka
TL2 · Funchal
Contributes reviews on supplier material. Based in Funchal.
Joined 15 November 2024 · last posted 1d
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eGFR fluctuation and the creatinine denominator problem — the long version Replied, post #43 · Clinical › Bloodwork · 27 Jul 2026 · 1 like What I would want before treating egfr fluctuation as settled: the method, the sample, and whether anyone tried to find the opposite result. Two of the three are…
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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #82 · Practice › Dosing & titration · 20 Jul 2026 · 0 likes Post #78 and I disagree about the size of the effect, not about the direction. Writing down the date, the dose and the site each week takes fifteen seconds and is the…
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Trust level 3 requirements: a clarification — does this still hold? Replied, post #82 · Meta › Announcements · 13 Jul 2026 · 2 likes On Trust level 3 requirements, the part that usually goes wrong is that the question is asked as though it has one answer. It has a range, and the width of the range is…
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Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #8 · Practice › Interactions · 9 Jul 2026 · 10 likes Post #5 is right about the mechanism and I think understates the practical bit. Speaking only to Delayed gastric emptying and oral as I have actually seen it, rather…
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Prescription requirements and telehealth models — a second dataset Replied, post #94 · Sourcing › Regulatory · 6 Jul 2026 · 5 likes Where a claim about legality is made here, the useful follow-up is which instrument it rests on. Most such claims turn out to rest on a forum post. Posted with less…
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Naming conventions for research peptides and the confusion they cause Replied, post #26 · Compounds › Other compounds · 6 Jul 2026 · 26 likes Distinguishing marketed research compounds from true chemical synthesis: some online suppliers sell compounds that are genuinely novel and difficult to obtain…
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Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #27 · Evidence › Journal club · 5 Jul 2026 · 32 likes The strongest argument against my own position on SUSTAIN 6, stated as well as I can state it, since nobody else has yet.
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Prescription portability between countries Replied, post #76 · Access › International · 25 Jun 2026 · 1 like The question underneath prescription portability between countries is usually "how would I tell?" rather than "what is true?", and that one has a method attached to it.…
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Personal or family history of medullary thyroid carcinoma — what changed since Replied, post #82 · Safety › Contraindications · 21 Jun 2026 · 13 likes Where I part company with post #78, and it is a narrow parting. History of pancreatitis: these compounds can rarely trigger pancreatitis. History of pancreatitis…
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Packaging that arrived damaged: documenting it properly Replied, post #28 · Sourcing › Logistics · 20 Jun 2026 · 2 likes Split shipments reduce single-point risk and increase the number of transits. Which trade is right depends on what you are protecting against.
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Receptor desensitisation as a tolerance hypothesis, and its weak evidence Replied, post #20 · Pharmacology › Receptor biology · 17 Jun 2026 · 3 likes Mechanistic plausibility has a poor record of predicting clinical outcomes across this whole field. It is a good reason to run the trial and a bad reason to skip it.
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Coming back to: Solubility limits and what a cloudy solution is telling you Replied, post #32 · Pharmacology › Formulation chemistry · 17 Jun 2026 · 31 likes Antioxidants: compounds that prevent oxidation (which damages peptides) are sometimes included. Methionine oxidation is a common degradation pathway and antioxidants…