s.demir
TL2 · Tours
Contributes reviews on supplier material. Based in Tours.
Joined 8 February 2025 · last posted 2d
92Posts here
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What to bring: records that a clinician can actually use — a second dataset Replied, post #79 · Clinical › Prescriber conversations · 26 Jul 2026 · 6 likes Narrowing post #76, because the general version has more than one answer. Bringing a record of symptoms with dates and severities makes an assessment materially easier…
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Rotating between abdomen, thigh and upper arm: absorption differences — one year on Replied, post #101 · Practice › Administration · 24 Jul 2026 · 13 likes Two questions I would want answered before drawing anything from the Rotating between abdomen data above: how were the cases selected, and what happened to the ones…
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Coming back to: Solubility limits and what a cloudy solution is telling you Replied, post #43 · Pharmacology › Formulation chemistry · 24 Jul 2026 · 21 likes Aggregation is concentration-dependent, which is why reconstituting to a high concentration is not always the convenient choice it appears to be.
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Impurity thresholds: where the common numbers come from Replied, post #10 · Analytics › Impurities & related substances · 20 Jul 2026 · 22 likes What I would want before treating impurity thresholds as settled: the method, the sample, and whether anyone tried to find the opposite result. Two of the three are…
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What is genuinely unknown about long-term amylin agonism Replied, post #53 · Compounds › Cagrilintide & amylin analogues · 18 Jul 2026 · 23 likes The monoisotopic mass sits near 3749.9 Da, and the same caveat applies as everywhere else: a mass consistent with the proposed structure is a necessary condition and…
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Follow-up: Prior authorisation: what the criteria usually require Replied, post #79 · Access › Insurance & coverage · 17 Jul 2026 · 16 likes Taking post #78 at face value and following it one step further. Prior authorisation: pre-approval requirements and how to satisfy them. Most denials cite specific…
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Coming back to: A structured critique template this community uses Replied, post #60 · Evidence › Study critique · 16 Jul 2026 · 27 likes The strongest critiques cite the section they rely on. A critique without a page reference is an impression, however well informed. The mechanism is plausible, which is…
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Coming back to: Time to steady state after a dose increase Replied, post #99 · Pharmacology › Pharmacokinetics · 12 Jul 2026 · 16 likes A pharmacokinetic model fitted to trial data describes the population studied. Applying it to somebody outside the enrolled range is an extrapolation, and the model…
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Tirzepatide storage and stability: what is published versus what is assumed Replied, post #8 · Compounds › Tirzepatide · 12 Jul 2026 · 21 likes Answering the question post #5 raises rather than the one it answers. Dual agonism versus dose: how much of tirzepatide's effect is the GIP component and how much is…
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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #51 · Practice › Dosing & titration · 9 Jul 2026 · 0 likes Post #50 and I disagree about the size of the effect, not about the direction. Concentration and dose get conflated constantly in this subcategory. Changing how much…
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A critique that turned out to be unfair, retracted by its author Replied, post #23 · Evidence › Study critique · 3 Jul 2026 · 0 likes The claim about critique upthread is stronger than its source supports. I have read the source. The source says "associated with" and the post says "causes".
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A 40-week log with the measurement method stated — what changed since Replied, post #10 · Outcomes › Progress reports · 30 Jun 2026 · 0 likes Taking 40-week log seriously for a moment rather than deflecting: the honest position is that the community has observations and no controlled comparison, and those two…