s.stavrianos
TL2 Member · Winnipeg, CA
Keeps a personal log and shares the numbers when they are relevant, with the measurement caveats attached.
Joined 21 March 2025 · last posted 2d
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Follow-up: The retatrutide phase 2 obesity paper, read closely Replied, post #24 · Compounds › Retatrutide · 26 Jul 2026 · 5 likes Post #23 is the version of this I will quote in future. One addition. Dose-response in the phase 2 obesity work was clear across the studied range, with no obvious…
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[2026 update] Documenting an adverse event properly Replied, post #21 · Safety › Adverse events · 25 Jul 2026 · 28 likes Reporting to regulatory agencies: if you have had a serious event, reporting it to the regulatory agency in your country can help with signal detection across the…
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CJC-1295 with and without DAC: what the modification does Replied, post #117 · Compounds › Secretagogues & GH axis · 20 Jul 2026 · 11 likes The practical version of CJC-1295 is three sentences long. The rigorous version is three pages and reaches the same conclusion with the conditions attached.
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Forced degradation studies: designing one that is informative Replied, post #96 · Analytics › Method validation · 11 Jul 2026 · 0 likes Nobody has said the unglamorous part of forced degradation studies yet, so: most of the variation is explained by things that are boring to write about and easy to check.
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Follow-up: Sleep quality changes during weight loss Replied, post #66 · Wellbeing › Sleep · 10 Jul 2026 · 0 likes Gastrointestinal effects overnight: nausea or reflux or constipation at night can disrupt sleep. Dosing timing (morning versus evening) might help if nighttime GI…
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Revisiting: What pooling buys you and what it destroys Replied, post #75 · Evidence › Meta-analyses · 1 Jul 2026 · 24 likes Reframing pooling buys slightly, because I think the disagreement is about the question rather than the answer. If the question is "does it happen", yes. If it is "how…
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Personal or family history of medullary thyroid carcinoma — what changed since Replied, post #77 · Safety › Contraindications · 17 Jun 2026 · 0 likes Coming back to post #75, because the follow-up matters more than the original answer. Allergy to the specific compound: true allergy is rare but possible. Any prior…
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Second pass at: Programming during a large energy deficit Replied, post #30 · Nutrition & Training › Resistance training · 16 Jun 2026 · 26 likes Post-weight-loss training: once weight loss is complete and energy deficit ends, training can shift to building again. The transition from preservation mode to building…
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Why this subcategory is stricter about sourcing than most Replied, post #42 · Compounds › Secretagogues & GH axis · 13 Jun 2026 · 2 likes Where I part company with post #40, and it is a narrow parting. Storage: these are lyophilised short peptides and are generally reasonably stable dry and considerably…
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[2026 update] Interpreting a result that disagrees with the supplier's certificate Started this topic · Sourcing › Independent verification · 3 Jun 2026 · 38 likes On the subject in the title: Interpreting a result that disagrees with the supplier's certificate Working notes rather than a conclusion. Structured report rather than…
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GLP-1 receptor distribution: central and peripheral Replied, post #58 · Pharmacology › Receptor biology · 28 May 2026 · 0 likes Central versus peripheral action: GLP-1 agonism works through both central nervous system effects (appetite) and peripheral effects (gastric motility, insulin). The…
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Why the titration planner refuses to produce a schedule below a floor Replied, post #77 · Data & Tools › Calculators · 23 May 2026 · 3 likes Dose equivalence calculator: compounds have different potencies. The calculator is provided with a caveat: "equivalence" is not precise and individual response varies.…