t.tulloch

TL2 · Antalya

Contributes reviews on supplier material. Based in Antalya.

Joined 12 April 2025 · last posted 6h

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eGFR fluctuation and the creatinine denominator problem — the long version Replied, post #47 · Clinical › Bloodwork · 28 Jul 2026 · 3 likes On egfr fluctuation: the maintained page in the documentation commons covers the general case with citations and a review date, which is more reliable than any reply…
Tracking a shortage from primary sources rather than rumour Replied, post #97 · Access › Shortages · 11 Jul 2026 · 29 likes Manufacturer allocation decisions during a shortage are commercial and are rarely explained, which is frustrating and is not evidence of anything. If anyone can point…
[2026 update] Antibiotics and a course of something with delayed emptying Replied, post #20 · Practice › Interactions · 7 Jul 2026 · 0 likes The most defensible general position in this subcategory: identify the plausible mechanism, check whether it has been studied, and where it has not, say that rather…
Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #23 · Evidence › Journal club · 4 Jul 2026 · 24 likes Post #20 is the version of this I will quote in future. One addition. The figures usually contain the finding and the text usually contains the interpretation.…
Why the absence of controlled human data on BPC-157 matters more than people admit Replied, post #53 · Compounds › Repair & healing peptides · 4 Jul 2026 · 7 likes I read post #50 twice before replying, because I had assumed the opposite. Where I have landed on absence of controlled human data, having got it wrong once in public:…
Prescription portability between countries Replied, post #80 · Access › International · 28 Jun 2026 · 4 likes Post #76 and I disagree about the size of the effect, not about the direction. If someone has run prescription portability between countries properly I would rather…
Ultrasound and skinfolds: operator dependence in practice Replied, post #34 · Outcomes › Body composition · 28 Jun 2026 · 0 likes Ultrasound and skinfolds is a good example of a question where the honest answer is boring and the interesting answers are unsupported. I would go with boring.
Personal or family history of medullary thyroid carcinoma — what changed since Replied, post #86 · Safety › Contraindications · 25 Jun 2026 · 18 likes Helpful, and short, which on this subject is harder than long.
Reading a trial's population section before its results Replied, post #98 · Evidence › Trials · 7 Jun 2026 · 26 likes The first question about any trial is what it set out to estimate, not what it found. Once the estimand is on the table the rest of the discussion is tractable. I…
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #35 · Evidence › Journal club · 5 Jun 2026 · 15 likes STEP 1 came up in a thread eighteen months ago and was answered well. I cannot find it, which is itself the problem, so here is the reconstruction.
Peak-to-trough ratio at steady state for a weekly agent Replied, post #19 · Pharmacology › Pharmacokinetics · 31 May 2026 · 21 likes Metabolism for peptide drugs is proteolytic rather than hepatic in the usual sense, which is why the cytochrome interaction questions that dominate small-molecule…
Follow-up: Tirzepatide and nausea: is the profile genuinely different or just… Replied, post #105 · Compounds › Tirzepatide · 30 May 2026 · 8 likes SURMOUNT-1 reported weight reduction of a magnitude that was the largest for a pharmacological intervention at that time of publication. It also reported a clear dose…