Topic summary

[2026 update] Antibiotics and a course of something with delayed emptying

Practice › Interactions metformin needs a source delayed gastric emptying insulin hypoglycaemia

This is a generated summary. It shows the 9 most-liked posts from a topic of 98, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

e.vargaTL230 Jun 2026 · edited#2

The opening post put the caveat in the right place and I want to underline it.

I have no financial interest in anything named in this thread and I want to say so before I comment on Antibiotics, because it is the sort of subject where it matters.

26 likes 28d

m.ramosTL27 Jul 2026#18

Narrowing post #16, because the general version has more than one answer.

Whatever the answer on Antibiotics turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, invite the correction.

28 likes 21d

o.vukovicTL28 Jul 2026#23

Building on post #20 rather than restating it.

SGLT2 inhibitors: frequently co-administered and relevant to renal and cardiovascular discussion, not to interactions. There is no pharmacokinetic interaction of concern.

27 likes 20d

a.schaefferTL2Member14 Jul 2026#44

s.karlsen_rph, post #22: Reporting rather than recommending, on Antibiotics. What happened is above. Whether it should have is a different question and not one I am qualified to answer. Go to post

Anticoagulant questions come up regularly and are the clearest case for professional advice rather than discussion, because the consequence of being wrong is not gradual.

Worth checking against a second source before it gets quoted onward.

33 likes in reply to #22 14d

d.oyelaranTL3Pharmacist18 Jul 2026#57

I disagree with the framing of Antibiotics above, and I think it is a substantive disagreement rather than a terminological one. Setting out why, so it can be checked.

The reasoning depends on an assumption that is doing a lot of work and is never stated. If the assumption holds, the conclusion follows. I do not think it holds generally.

27 likes 10d

k.marchandTL222 Jul 2026#77

Practical answer on Antibiotics, since the theoretical one is upthread: do the simplest check first, write down the result, and only then decide whether the complicated explanation is needed. It usually is not.

31 likes 5d

f.villalobosTL225 Jul 2026#87

l.vukovic, post #35: Thyroid medications: semaglutide is associated with a slowing of gastric emptying, which might affect thyroid medication absorption if they are taken very close together. Separating them by a few hours is the conservative approach. Go to post

SGLT2 inhibitors: frequently co-administered and relevant to renal and cardiovascular discussion, not to interactions. There is no pharmacokinetic interaction of concern.

30 likes in reply to #35 3d

septum_entryTL2Member26 Jul 2026#90

Oral medications versus time: if you take an oral medication 30 minutes before semaglutide (which slows gastric emptying), the delayed stomach emptying affects when and where the oral medication is absorbed. Separating by a larger interval (1 to 2 hours) usually resolves this.

29 likes 2d

appeals_deskTL3Regular27 Jul 2026#97

k.marchand, post #77: Practical answer on Antibiotics, since the theoretical one is upthread: do the simplest check first, write down the result, and only then decide whether the complicated explanation is needed. It usually is not. Go to post

Delayed gastric emptying is the mechanism behind most of the plausible interactions in this class: anything whose absorption depends on how quickly the stomach empties can behave differently.

I would treat the number as indicative rather than as a measurement.

28 likes in reply to #77 18h

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Alcohol: what is documented and what is folklore — the long versionPractice › Interactions · 13 replies

Moved from Side effects by s.leclerc. Category placement is not obvious from outside and getting it wrong is expected. This topic will get better answers here. The move is recorded in the public log citing R7.

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